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Brief Communication

Nature Neuroscience 10, 1395–1397 (1 November 2007) | doi:10.1038/nn1987

Genetic control of instrumental conditioning by striatopallidal neuron|[ndash]|specific S1P receptor Gpr6

Mary Kay Lobo , Yijun Cui , Sean B Ostlund , Bernard W Balleine & X William Yang

Instrumental conditioning allows animals to learn about the consequences of their own actions, but the underpinning molecular mechanisms remain elusive. Here we show that the sphingosine-1-phosphate (S1P) receptor Gpr6 is selectively expressed in the striatopallidal neurons in the striatum.