Article abstract
Nature Neuroscience 10, 1474 - 1482 (2007)
Published online: 7 October 2007 | doi:10.1038/nn1976
Sensory processing in the Drosophila antennal lobe increases reliability and separability of ensemble odor representations
Vikas Bhandawat1, Shawn R Olsen1,2, Nathan W Gouwens1,2, Michelle L Schlief1,2 & Rachel I Wilson1
Abstract
Here we describe several fundamental principles of olfactory processing in the Drosophila melanogaster antennal lobe (the analog of the vertebrate olfactory bulb), through the systematic analysis of input and output spike trains of seven identified glomeruli. Repeated presentations of the same odor elicit more reproducible responses in second-order projection neurons (PNs) than in their presynaptic olfactory receptor neurons (ORNs). PN responses rise and accommodate rapidly, emphasizing odor onset. Furthermore, weak ORN inputs are amplified in the PN layer but strong inputs are not. This nonlinear transformation broadens PN tuning and produces more uniform distances between odor representations in PN coding space. In addition, portions of the odor response profile of a PN are not systematically related to their direct ORN inputs, which probably indicates the presence of lateral connections between glomeruli. Finally, we show that a linear discriminator classifies odors more accurately using PN spike trains than using an equivalent number of ORN spike trains.
- Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA.
- These authors contributed equally to this work.
Correspondence to: Rachel I Wilson1 e-mail: rachel_wilson@hms.harvard.edu
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