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Here, the authors perform statistical analyses to demonstrate that epistasis is highly pervasive in adaptive evolutionary trajectories of enzymes. Using epistatic data, they expose higher-order rewiring of intramolecular amino acid networks.
Janus particles commonly exhibit a high-symmetry patch, constraining the range of possible assemblies. Here, the authors devise a synthetic approach to fine-tune the patch symmetry in Janus particles and showcase the assembly of these particles into chiral colloidal clusters.
Cheese fermentation and flavour formation are the result of complex biochemical reactions driven by the activity of multiple microorganisms. Here, the authors identify microbial interactions as a mechanism underlying flavour formation in Cheddar cheese.
Van der Waals antiferromagnets offer a unique platform for studying magnetism in reduced dimensions, however, the low dimensionality, combined with lack of net magnetization, renders investigation challenging with conventional experimental probes. Here, Houmes et al show how van der Waals antiferromagnets can be investigated via the resonances of a vibrating rectangular membranes of this material.
Coacervate droplets are promising protocells that sequester nutrients, but how new peptides could be synthesized inside coacervates remains a mystery. Here, the authors develop redox-active coacervates that facilitate the formation of new peptide bonds.
Heterozygous deletions in the ANKS1B gene cause ANKS1B neurodevelopmental syndrome. Here the authors show this syndrome is associated with impaired white matter integrity, and that Anks1b-deficient mouse models display deficits in oligodendrocyte maturation, myelination, and Rac1 function.
Gas sensors typically detect only few specific gases; the authors show a broad-spectrum sensor based on correlated 2-dimensional electron gas (C-2DEG), which detects various gases quantitatively and measures partial pressures, through a purely physical mechanism.
A differentiable design framework that integrates both geometrical and magnetomechanical analyses to inversely program the shape morphing in magnetically actuated kirigami is proposed, achieving intricate shapes and multistate transitions.
With redox-linked synthetic biology and electrobiofabrication, electronic information can be transmitted in a bidirectional manner between biology and electronics. Here the authors design an electrogenetic platform that allows real time electronic control of biological functions from proteins and gene circuits to cell consortia.
Variation in human telomere length has been well studied, but most previous studies have used adult telomere length. Here, the authors explore the genetic basis of telomere length in the placenta and find suggestive causal genes modulating human telomere length.
The ability of BCG vaccination to prevent pulmonary tuberculosis could be improved by targeting mucosal immunity within the lung. Here the authors compare latent Mtb-infected donors with intradermal or oral BCG vaccine recipients to show distinct systemic and pulmonary immune responses are induced by differing routes of natural infection or vaccination.
How brain regions communicate to support the learning and recall of rich memories is not fully understood. Using recordings of electrical activity deep within the brains of human patients, the authors discovered a role for the theta rhythm in allowing this bidirectional dialogue across brain regions to happen.
Invariant natural killer T (iNKT) cells have recently been reported to play a key role in adipose tissue homeostasis. Here, the authors show that adipose tissue iNKT cells mediate immune responses that control adipocyte turnover in mice.
The diversity of ESBL-producing Klebsiella pneumoniae species complex and ESBL-Escherichia coli within patients is low and colonization with the same strain may persist for long periods. Authors utilise clinical and microbiological data from electronic health records to investigate genetic diversity of colonizing and infecting strains.
Singh et al. show how the M. tuberculosis methyltransferase Rv2067c outsmarts host epigenetic machinery by methylating histone H3 prior to its assembly into nucleosomes, thereby ensuring the pathogen’s intracellular survival/success.
A solvent-pair surfactants enabled assembly method is developed to achieve a general and programmable synthesis of mesoporous metal oxides via the association of POMs with block copolymers through indirect interaction.
It is unclear how dorsomedial prefrontal cortex and insula represent reward prediction errors. Here, the authors analyze human intracranial data to reveal spatially mixed, asymmetric coding of valence-specific and unsigned reward prediction errors, with insula leading dorsomedial prefrontal cortex.
Zuiderveen and colleagues find that emerging bio-based products have on average 45% lower greenhouse gas life cycle emissions compared to their fossil counterparts, yet, there is a large variation between individual bio-based products with none of them reaching netzero emissions.
Here the authors present the crystal structure of a bacterial STING. The structure shows that bacterial STING can modulate immune responses by forming anti-parallel dimers or, in certain species, through the presence of a long lid.
Impromptu communications are indispensable for disaster-prone regions with damaged infrastructure. Here, the authors propose a mechanically actuated bi-stable reconfigurable quadrifilar helix antenna suitable for both terrestrial and satellite L-band communications.