Articles in 2019

The neural mechanisms that lead to a relative deficit in memory retrieval in the afternoon are unclear. Here, the authors show that the circadian - dependent transcription factor BMAL1 regulates retrieval through dopamine and glutamate receptor phosphorylation.

Distributed acoustic sensing (DAS) technology in geophysics is commonly known for applications such as active source seismic profiling in boreholes. Here, the authors convert the fiber optics cable into an ocean bottom seismic recording array with thousands of single component channels.

Here, the authors study the interference effects between different multipole transition channels by coupling a molecule to a plasmonic nanoantenna. Controlling different emission pathways of quantum emitters allows selective enhancement or suppression of the transition rate through devoted illumination schemes.

Ultrafast molecular relaxation can be probed with short laser pulses. Here the authors study collisional behavior of a N₂O and He mixture beyond secular approximation by aligning them using laser pulses and probing their rotational echoes.

Here, Gassen et al. show that S-phase kinase-associated protein 2 (SKP2) is responsible for lysine-48-linked poly-ubiquitination of beclin 1, resulting in its proteasomal degradation, and that inhibition of SKP2 enhances autophagy and reduces replication of MERS coronavirus.

The photovoltaics market has been dominated by crystalline silicon solar cells despite the high cost of the silicon wafers. Here Zou et al. develop a one-step electrodeposition process in molten salt to produce high-purity solar-grade silicon films, delivering power conversion efficiency of 3.1%.

Correlation effect is essential to stabilize exotic phases such as superconductivity in twisted bilayer graphene. Here, Yuan et al. predict significantly enhanced electron correlation effects due to an emergent high-order van Hove singularity in a two dimensional moiré superlattice.

Though highly emissive charge-transfer type molecules in a host matrix is an attractive material for organic opto-electronics, concentration quenching limits photoluminescence quantum yield. Here, the authors report concentration quenching in fluorophores based on spontaneous exciton dissociation.

Optical solitons have been studied in a variety of systems for their unique properties. Here, the authors report on optically observed solitonic supramolecules, made up of large-scale structures of many solitons interacting within a fiber cavity, and study their fundamental characteristics.

The anti-vascular endothelial growth factor (VEGF) antibody bevacizumab has shown efficacy for the treatment of neurofibromatosis type 2 (NF2). Here, the authors show that VEGFRs peptide vaccination can improve hearing and reduce tumor volume in NF2 patients, including in previously bevacizumab resistant tumors.

Carbonate weathering captures CO₂ and represents a large sink of terrestrial carbon that is threatened by climate and land-use change. Here the authors build a model that predicts drivers of carbonate weathering into the future, determining that runoff is an overlooked controlling factor.

Feedback mechanisms for synthetic gene circuits are necessary to provide robustness to external perturbations. Here the authors validate a biomolecular controller based on a sigma and anti-sigma factor to achieve stable gene expression in the face of external disturbances in an in vitro synthetic gene circuit.

PRDM9 is a PR domain containing histone methyl transferase which expression is normally restricted to the germline that has also been linked to a number of somatic cancers. Here the authors describe the identification of a small molecule that selectivity inhibits the methyltransferase activity of PRDM9 in biochemical and cellular assays

Design of materials which allow for simultaneous detection and removal of water pollutants is challenging. Here the authors develop a guanidinocalix[5]arene that selectively binds perfluorinated alkyl substances and allows for fluorescence detection as well as removal of the pollutants in contaminated water.

Tradeoffs are central to life history theory and evolutionary biology, yet almost nothing is known about their mechanistic basis. Here the authors characterize one such mechanism and find a transposable element insertion is associated with the switch between alternative life history strategies.

Cancer therapy using oncolytic virus has shown pre-clinical and clinical efficacy. Here, the authors report ExtraCRAd, an oncolytic virus cloaked with tumour cell membrane and report its therapeutic effects in vitro and in vivo in multiple mouse tumour models.

The autophagic and Hippo pathways are both well characterized contributors to cancer. Here, Tang et al show that LATS1, but not LATS2, negatively regulates autophagy by promoting Beclin1 ubiquitination, which restricts lethal autophagy induced by sorafenib treatment in cancer cells.

Birch pitch is thought to have been used in prehistoric times as hafting material or antiseptic and tooth imprints suggest that it was chewed. Here, the authors report a 5,700 year-old piece of chewed birch pitch from Denmark from which they successfully recovered a complete ancient human genome and oral microbiome DNA.

The Z-ring, constituted of the tubulin homolog FtsZ protein, plays an essential role for bacterial cell division. Here the authors use an in vitro reconstitution approach to determine how the regulatory protein ZapA affects FtsZ treadmilling and filament organization into large-scale patterns.

The poly(ADP-ribose) polymerases play a key role in maintaining genomic integrity by detecting DNA damage and mediating repair. Here the authors characterize the kinetics of PARP1 binding to a variety of nucleosomes harbouring DNA double-strand breaks.