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Three-dimensional DNA origami constructs can be used to deliver vaccine antigens in a multi-valent form. Here the authors design a DNA origami system for SARS-CoV-2 proteins and characterize in mice the immune response and protective capacity of generated antibodies, finding that the construct itself is not immunogenic.
Designing catalysts with atomically synergistic sites shows great promise as a pathway for advanced catalyst development. Here the authors report Zn-Cr catalyst with atomically binuclear active sites for iso-stoichiometric co-conversion of ethane and CO2 through proximal atomic synergy.
Increasing deposition of dissolved inorganic nitrogen in coastal oceans through the atmosphere and rivers exacerbate the deficiency of phosphate which stimulates the utilization of dissolved organic phosphorus by phytoplankton.
Low temperature ionic conducting materials such as OH- and H+ ionic conductors are important electrolyte materials. Here the authors report the discovery of fast mixed OH- /H+ conductors in ceramic materials, SrZr0.8Y0.2O3-δ and CaZr0.8Y0.2O3-δ, for potential use as electrolytes in fuel cells.
Thyroid dysfunction is involved in many diseases. Here, the authors provide insights into the genetics and biological pathways influencing important thyroid function parameters, showing potential causal effects on many clinical outcomes.
In rats, functional ultrasound imaging reveals that blocking opioid receptors modulates the effects of subanesthetic ketamine on neural activity in males but not in females, with parallel changes in ketamine’s effects on brain structure and behavior.
Here, the authors develop a high-throughput method to quantify Bifidobacterium longum subsp. infantis (BL. infantis), a proficient HMO-utilizer, from metagenomic sequencing, and applied it to a longitudinal cohort consisting of 21 mother-infant dyads, suggesting BL. infantis colonization to start late in the breast-feeding period.
The electrochemical reduction of CO for sustainable fuel production has gained attention, but the reaction mechanism needs further clarification. Here the authors delve into the discussion regarding whether the rate-determining step for the generation of multi-carbon products is the C-C coupling or the hydrogenation of CO, and provide evidence for dimerization of two *CO as the pivotal step in this process.
Single cell profiling of tissue from patients undergoing therapy has the potential to identify drug-induced immune changes. Here the authors show a skin scRNA-seq study of psoriasis patients treated with an IL-23 inhibitor and characterize changes in cell states during early treatment.
It is challenging to achieve simultaneous robustness, permeability and high electrical performance when patterning textile electronics. Here, the authors report an in-textile photolithography method for precise metal patterns while maintaining the 3D porous structure for wearable textile electronics.
Here, Shao et. al attribute the reduction in bone mechano-responsiveness seen in type 2 diabetes to abnormal osteocytic calcium dynamics. They identify reduced SERCA2 pump activity as a mediator of this process and show that rescuing SERCA2 significantly improves bone mechanical adaptation in this context.
Shi and Li et al. show that SARS-CoV-2 Omicron subvariants have increased capacity to infect primary human nasal tissue using a distinct entry route that depends on matrix metalloproteinases as opposed to TMPRSS2 used by previous variants, which enables evasion from antiviral factors.
Thermochromic perovskite smart windows require humidity for operation, but too much can lead to degradation. Tso and coworkers demonstrate a mask-inspired system for humidity regulation, to extend lifespan and minimize optical haze.
It is unclear why flying insects congregate around artificial light sources. Here, the authors use high-speed videography and motion-capture, finding that insects fly perpendicular to light sources due to a disruption of the dorsal light response.
Nziza et al. profile anti-SARS-CoV-2 antibody responses in infants and toddlers after mRNA vaccination and demonstrate a strong functional activation of humoral immunity in this age group when compared with adults and naturally infected children.
Recent work proposed a machine learning algorithm for predicting ground state properties of quantum many-body systems that outperforms any non-learning classical algorithm but requires extensive training data. Lewis et al. present an improved algorithm with exponentially reduced training data requirements.
Mast cells serve as sentinels for mucosal infection. This study shows how mast cells can differentially detect extracellular and invasive gut bacteria, and in response tune their cytokine production to signal different levels of danger.
Both particle and wave energy exist in plasma and energy transfer leads to many interesting phenomena like turbulence, particle acceleration. Here the authors show electron-scale coherent structure resulting from energy transfer in magnetosheath using a model and data from Magnetospheric Multiscale Mission.
The formation of artificial light-harvesting systems with high donor/acceptor ratios for efficient energy transfer remains challenging. Here, the authors describe a polymeric supramolecular column-based light-harvesting system by modular columnar assembly of donor/acceptor chromophores, enabling superior light-harvesting efficiency and dynamic full-color tunable emission.
Acquired mutations of the gene UBA1 occurring in myeloid cells that result in the expression of impaired isoforms of the enzyme E1 have been described in patients with a severe adult onset auto-inflammatory syndrome called VEXAS. Here the authors profile patients with UBA1 mutations presenting with or without VEXAS disease and show VEXAS disease is characterized by inflammasome activation and monocyte dysregulation.