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Catalytic asymmetric click reactions of azides and alkynes for chiral triazole synthesis remains a challenge, due to the limited catalytic systems and substrate scope. Herein, the authors report the enantioselective azidation/click cascade reaction of N-propargyl-β-ketoamides via copper catalysis, affording a variety of chiral 1,2,3-triazoles.
Asthma is one of the most common diseases in childhood and for which the UK has the highest mortality rates in Europe. Here, the authors show that the UK soft drinks industry levy was linked with a fall in hospital admissions for asthma in children
Polycyclic aromatic hydrocarbons such as [4]helicenes are important interstellar molecules. Here, the authors show their evolution of chiral clusters upon aggregation through coincidence spectroscopy and quantum chemical calculations.
Solar water splitting devices, though often demonstrated at atmospheric pressure, need to deliver H2 at high pressure for many applications. Here the authors use multiphysics model to evaluate the benefits and penalties of elevated pressure operation, identifying the optimum pressure range to enhance efficiency.
Sustained antidepressant effect of ketamine involves restoration of glutamatergic synapses. Here, authors show that several planar cell polarity proteins reduced with stress hormone administration and increased with ketamine treatment are required for synapse restoration.
The recharging and rapid self-discharge of supercapacitors imposes constraints on their application. In response, the authors have developed a moisture-powered supercapacitor capable of self-charging and voltage stabilizing by absorbing water in air.
The authors use scanning tunneling spectroscopy to investigate the evolution of quasiparticle interference in a single-layer cuprate compound. They find evidence for an emergent normal fluid in the superconducting ground state of overdoped samples, with the gapless quasiparticles located at the antinodal region of reciprocal space.
Complicated associations between multiplexed environmental factors and aging are poorly understood. Here, authors show heterogeneous associations of multiplexed environmental factors with multidimensional aging metrics.
Developing Type I photosensitizers (PSs) is vital for tackling hypoxic intolerance of photodynamic therapy in the hypoxic microenvironment, but elusive due to the lack of a general molecular design strategy. Here the authors report a universal and simple method to covert traditional Type II PSs to Type I PSs.
The uterine stroma only fully differentiates postnatally, but how this is regulated remains unclear. Here they show that postnatal uterine stromal development is mediated at an epigenetic level by PRSET7, which represses interferon response genes.
Targeted gene delivery to the brain is a critical tool for neuroscience research and has significant potential to treat human disease. Here the authors engineer the protein shell of a common gene therapy vector for enhanced efficiency and specificity of brain delivery in ultrasound-targeted brain regions.
Werner syndrome (WS) is a rare inherited disorder characterized by premature aging and atherosclerosis. Here, the authors mimic atherosclerosis with iPSC-derived macrophages and vascular cells and find that type I IFN signaling triggered by the reactivation of retrotransposable elements in WS macrophages induces vascular dysfunction.
Land management impacts ecosystem functions. Here, the authors conduct field experiments in Germany assessing ecosystem variables in cropland and grasslands showing that sustainable agricultural practices enhance ecological and economic benefits.
Resorption of myocardial scar and subsequent regeneration may be influenced by the extent of irreversible pyridinoline and deoxypyridinoline collagen cross-links that develop in the scar. Hydroxylation of lysine in collagen may regulate this process.
Thermal soaring, inspired by gliding birds, is an appealing model behavior for understanding motion control and how it is learned by animals and engineered autonomous systems. The authors propose a deep reinforcement learning framework to study the learning process of thermal soaring under horizontal wind conditions.
High-entropy ceramic dielectrics show promise for capacitive energy storage but struggle due to vast composition possibilities. Here, the authors propose a generative learning approach for finding high-energy-density high-entropy dielectrics in a practically infinite exploration space of over 1011 combinations.
Terpene synthesis is limited by the current availability of natural cyclic building blocks. In this study, the authors employ squalene-hopene cyclases in the chemoenzymatic synthesis of head-to-tail fused terpenes and generate ten chiral scaffolds with >99% ee and de, at up to decagram scale.