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Catalytic asymmetric click reactions of azides and alkynes for chiral triazole synthesis remains a challenge, due to the limited catalytic systems and substrate scope. Herein, the authors report the enantioselective azidation/click cascade reaction of N-propargyl-β-ketoamides via copper catalysis, affording a variety of chiral 1,2,3-triazoles.
Polycyclic aromatic hydrocarbons such as [4]helicenes are important interstellar molecules. Here, the authors show their evolution of chiral clusters upon aggregation through coincidence spectroscopy and quantum chemical calculations.
The recharging and rapid self-discharge of supercapacitors imposes constraints on their application. In response, the authors have developed a moisture-powered supercapacitor capable of self-charging and voltage stabilizing by absorbing water in air.
Complicated associations between multiplexed environmental factors and aging are poorly understood. Here, authors show heterogeneous associations of multiplexed environmental factors with multidimensional aging metrics.
The uterine stroma only fully differentiates postnatally, but how this is regulated remains unclear. Here they show that postnatal uterine stromal development is mediated at an epigenetic level by PRSET7, which represses interferon response genes.
Targeted gene delivery to the brain is a critical tool for neuroscience research and has significant potential to treat human disease. Here the authors engineer the protein shell of a common gene therapy vector for enhanced efficiency and specificity of brain delivery in ultrasound-targeted brain regions.
Werner syndrome (WS) is a rare inherited disorder characterized by premature aging and atherosclerosis. Here, the authors mimic atherosclerosis with iPSC-derived macrophages and vascular cells and find that type I IFN signaling triggered by the reactivation of retrotransposable elements in WS macrophages induces vascular dysfunction.
Land management impacts ecosystem functions. Here, the authors conduct field experiments in Germany assessing ecosystem variables in cropland and grasslands showing that sustainable agricultural practices enhance ecological and economic benefits.
Resorption of myocardial scar and subsequent regeneration may be influenced by the extent of irreversible pyridinoline and deoxypyridinoline collagen cross-links that develop in the scar. Hydroxylation of lysine in collagen may regulate this process.
Terpene synthesis is limited by the current availability of natural cyclic building blocks. In this study, the authors employ squalene-hopene cyclases in the chemoenzymatic synthesis of head-to-tail fused terpenes and generate ten chiral scaffolds with >99% ee and de, at up to decagram scale.
Faithful transfer of quantum states between different parts of a single complex quantum circuit will become more and more important as quantum computing devices grow in size. Here, the authors transfer single-qubit excitations, two-qubit entangled states, and two excitations across a 6 × 6 superconducting qubit device.
Here, the authors identify 200 Varicella-Zoster Virus (VZV) circRNAs, confirmed in HZ patient tissues. Numerous latency-associated transcripts (VLTs)-like circRNAs (circVLTslytic) were found with multiple exons and splice donor sequences that influence formation. circVLTslytic RNAs are non-essential for VZV replication but affect ACV sensitivity.
The bidirectional halide and silver migration cause irreversible chemical corrosion to electrodes and perovskite layer. Here, the authors employ 4,4’-dicyano-2,2’-bipyridine in the electron transport layer to coordinate silver and iodide, realizing stable solar cells with efficiency over 26%.
Chlamydia trachomatis invades host epithelial cells using the two effectors TarP and TmeA. Here, Romero et al find that host GTPase dynamin 2 is also recruited to invasion sites where it is required for uptake, and is regulated by TarP and TmeA.
Histidine kinases form part of bacterial two-component signaling systems (TCS). By modulating the balance between antagonistic kinase and phosphatase activities, the authors reprogram output and sensitivity of light-responsive TCSs, thus generating tools for gene-expression control by red light.
Membrane proteins play essential roles in biological processes but are very difficult to study due to their hydrophobic nature. Here, the authors apply the QTY code, a method for designing water soluble membrane proteins, to histidine kinase CpxA to render it completely water-soluble and preserve the native molecular function.
In this target trial emulation study, the authors evaluate effectiveness of nirmatrelvir/ritonavir in non-hospitalized paediatric patients aged 12–17 years with SARS-CoV-2 Omicron infection and show reduced risks of 28 day all-cause mortality or hospitalization associated with the treatment.
The preparation of C − N axially chiral compounds, a class of privileged scaffolds in pharmaceuticals, advanced materials and organic synthesis, has recently attracted significant interest. Herein the authors report a chiral dinitrogen ligand promoted asymmetric Catellani reaction for the synthesis of C–N axially chiral scaffolds.
The robust anion framework of ionic nanocrystals impedes shape change by cation exchange. Here, the authors report an anisotropic, regenerative transformation of Cu1.8S nanoplates during cation exchange.
Recently, studies have identified different low-density lipoprotein receptors as functional entry receptors for alphaviruses. In this Perspective, the authors compare the known alphavirus-receptor structures and discuss why it might be challenging to generate a broad-spectrum entry inhibitor.