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Catalytic asymmetric click reactions of azides and alkynes for chiral triazole synthesis remains a challenge, due to the limited catalytic systems and substrate scope. Herein, the authors report the enantioselective azidation/click cascade reaction of N-propargyl-β-ketoamides via copper catalysis, affording a variety of chiral 1,2,3-triazoles.
Complicated associations between multiplexed environmental factors and aging are poorly understood. Here, authors show heterogeneous associations of multiplexed environmental factors with multidimensional aging metrics.
The uterine stroma only fully differentiates postnatally, but how this is regulated remains unclear. Here they show that postnatal uterine stromal development is mediated at an epigenetic level by PRSET7, which represses interferon response genes.
Werner syndrome (WS) is a rare inherited disorder characterized by premature aging and atherosclerosis. Here, the authors mimic atherosclerosis with iPSC-derived macrophages and vascular cells and find that type I IFN signaling triggered by the reactivation of retrotransposable elements in WS macrophages induces vascular dysfunction.
Resorption of myocardial scar and subsequent regeneration may be influenced by the extent of irreversible pyridinoline and deoxypyridinoline collagen cross-links that develop in the scar. Hydroxylation of lysine in collagen may regulate this process.
Faithful transfer of quantum states between different parts of a single complex quantum circuit will become more and more important as quantum computing devices grow in size. Here, the authors transfer single-qubit excitations, two-qubit entangled states, and two excitations across a 6 × 6 superconducting qubit device.
The bidirectional halide and silver migration cause irreversible chemical corrosion to electrodes and perovskite layer. Here, the authors employ 4,4’-dicyano-2,2’-bipyridine in the electron transport layer to coordinate silver and iodide, realizing stable solar cells with efficiency over 26%.
Histidine kinases form part of bacterial two-component signaling systems (TCS). By modulating the balance between antagonistic kinase and phosphatase activities, the authors reprogram output and sensitivity of light-responsive TCSs, thus generating tools for gene-expression control by red light.
Membrane proteins play essential roles in biological processes but are very difficult to study due to their hydrophobic nature. Here, the authors apply the QTY code, a method for designing water soluble membrane proteins, to histidine kinase CpxA to render it completely water-soluble and preserve the native molecular function.
In this target trial emulation study, the authors evaluate effectiveness of nirmatrelvir/ritonavir in non-hospitalized paediatric patients aged 12–17 years with SARS-CoV-2 Omicron infection and show reduced risks of 28 day all-cause mortality or hospitalization associated with the treatment.
The preparation of C − N axially chiral compounds, a class of privileged scaffolds in pharmaceuticals, advanced materials and organic synthesis, has recently attracted significant interest. Herein the authors report a chiral dinitrogen ligand promoted asymmetric Catellani reaction for the synthesis of C–N axially chiral scaffolds.
The robust anion framework of ionic nanocrystals impedes shape change by cation exchange. Here, the authors report an anisotropic, regenerative transformation of Cu1.8S nanoplates during cation exchange.
Recently, studies have identified different low-density lipoprotein receptors as functional entry receptors for alphaviruses. In this Perspective, the authors compare the known alphavirus-receptor structures and discuss why it might be challenging to generate a broad-spectrum entry inhibitor.
Synthetic biology applications require finely tuned gene expression, often mediated by synthetic transcription factors. Here the authors validate two plant-derived proteins, FHY1 and FHL, acting as transactivators in mammalian cells for orthogonal, modular, and tunable control of gene transcription by forming a photosensing transcriptional regulation complex with PhyA.
While synthetic active matter research has concentrated on developing point-like, interacting entities, designing freely jointed active assemblies from autonomously powered components has remained a challenge. Here, the authors introduce freely jointed active polymers created from self-propelled droplets, uncovering emergent rigidity and propulsion, thereby advancing towards self-morphic synthetic materials.
Informal transportation services constitute the primary form of public transport in the Global South. Here, the authors analyze the structure of route networks in cities across the globe, showing how informal routes self-organize into consistent line services that often outperform centralized services in the Global North, exhibiting fewer detours and comparable interconnectivity.
By performing a tissue-specific transcriptome analysis, Zhang et al. show how age-related loss of germline stem/progenitor cells in C. elegans is regulated by a signal produced by non-niche cells within the same organ system.
To identify intracellular dynamics at the single-cell level, authors develop a scalable method via a divide-and-conquer strategy and apply it to a yeast transcription system. The results underscore the heterogeneity in isogenic cells, which is validated by a noise-decomposition method.
Developing artificial leaves is crucial for advancing Net Zero Future, but most artificial leaves rely on the use of metal or semiconductors catalysts that usually have a lower catalytic activity and selectivity compared to biocatalysts. Here the AUs report Ecoleaf, a biodegradable artificial leaf that mimics the controlled expansion and contraction of stomata and enables enzymic CO2 conversion.
Biological computing is a promising field with potential applications in biosafety, environmental monitoring, and personalized medicine. Here the authors create bio-computers using engineered E. coli colonies that respond to chemical gradients, producing different logic functions depending on how they are spatially arranged.