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Synthetic biology applications require finely tuned gene expression, often mediated by synthetic transcription factors. Here the authors validate two plant-derived proteins, FHY1 and FHL, acting as transactivators in mammalian cells for orthogonal, modular, and tunable control of gene transcription by forming a photosensing transcriptional regulation complex with PhyA.
Biological computing is a promising field with potential applications in biosafety, environmental monitoring, and personalized medicine. Here the authors create bio-computers using engineered E. coli colonies that respond to chemical gradients, producing different logic functions depending on how they are spatially arranged.
Hydrogels capable of swift mechanical energy dissipation are desirable for various uses, but traditional energy absorption in hydrogels typically relies on viscoelastic mechanisms and often suffers from slow recovery. Here, the authors report a hydrogel design harnessing molecular friction to achieve efficient energy dissipation and rapid recovery.
Topological waves and their exotic properties are attracting intense research interest. Here, the authors report on the discovery of supertoroidal electromagnetic pulses with robust skyrmionic topology that persists upon propagation over arbitrarily long distances.
Creating highly active materials that effectively harness solar spectra is essential for photocatalysis, though challenging. Here the authors introduce a novel donor-acceptor covalent organic framework with a broad absorption range of 200 nm to 900 nm, achieving efficient artificial photocatalytic amine coupling.
Aligned collagen I is associated with the emergence of leader cells that are responsible for collective invasion. Here, the authors show that Collagen I and Yap signalling are in a feed-forward loop to drive the collective invasion of basal-like tumour cells.
Brain evolution at the cellular level is understudied. Here, the authors compare olfactory circuits from three Drosophila species, finding species-specific connectivity patterns associated with food odours and suggesting that more connectivity may be related to learning performance.
In this work, authors show that exacerbations of respiratory symptoms in persons with cystic fibrosis (CF) were associated with either CF pathogen-driven or anaerobe-based changes in airway bacterial community structure.
Omecamtiv mecarbil and Mavacamten are small molecules directly modulating the force produced by β-cardiac myosin. In this work, the authors describe how the modulators Omecamtiv mecarbil and Mavacamten can have opposite effects on cardiac myosin force production despite occupying the same pocket.
Limited data hinders accurate predictions of strength and permeability of permeable cement-stabilized base materials. Here, the authors propose a kriging-based surrogate model assisted neural networks, which improves accuracy by 21% over traditional models.
RH5, which is part of the trimeric RCR-complex essential for invasion, is a vaccine candidate for malaria. Here, Williams et al. show that monoclonal antibodies targeting each of the three proteins in the RCR-complex can work together to more effectively block the invasion of red blood cells by Plasmodium falciparum and design a combination vaccine candidate.
The role of ancestry in target discovery remains to be systematically explored. Here, the authors analyse data from 611 genome scale CRISPR/Cas9 viability experiments in human cell line models as part of The Cancer Dependency Map and identify ancestry-associated genetic dependencies.
Human methyltransferase MLL4 mediates embryonic development and is dysregulated in diseases. Zhang et al. found that binding of PHD fingers of MLL4 to ASXL1/2 is required for recruitment of the deubiquitinase BAP1 to MLL4-bound active enhancers in vitro.
Implementing point spread function (PSF) engineering in high-throughput microscopy has proved challenging. Here, the authors propose a compact PSF engineering approach, which allows for enhanced depth of field and for the recovery of 3D information using single snapshots.
The development of methodologies to construct fast-moving, biodegradable polymeric nanomotors remains a challenge. Here, the authors present a light-propelled nanomotor by adorning the surface of bowl-shaped stomatocytes with gold nanoparticles achieving particle translocation in mammalian cells through the temporary disruption of the cell membrane.
Here, authors highlight ecological risks of a widely used disinfectant, chloroxylenol, and identify a more efficient and safer alternative from halo-phenolic disinfection byproducts, 2,6-dichlorobenzoquinone. They leverage seawater’s slightly alkaline nature to enhance its degradability via hydrolysis.