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The authors observe THz emission from Ni/Pt heterostructure due to long-range ballistic orbital transport. The velocity of orbital current can be optically tuned by laser fluence, opening the avenue for future optorbitronic devices.
Recent seismological studies challenge the traditional view that the interface between the core and mantle is a straightforward discontinuity. As seismology is pushed to its observational limits, a complex - potentially compositionally layered - region between the core and mantle is emerging.
Chirality has long fascinated chemists, but asymmetric synthesis has largely focused on central, axial, and helical chirality to date. Here, the authors synthesize dianthranilides with planar chirality, via cinchona alkaloid-catalyzed (dynamic) kinetic resolution.
By resonant pumping the organic cation in 2D perovskite, Fu et al. report the electronic and mechanical couplings between the organic and inorganic sublattices, evidenced by the reduced bandgap and modified lattice degree of freedom within the inorganic sublattice, and slow heat transfer process.
Phosphanorcaradienes can serve as synthons for transient phosphinidene but the synthesis remains challenging. Here, the authors report a synthesis protocol for a phosphanorcaradiene, in which one of the benzene rings is intramolecularly dearomatized through attachment to the phosphorus atom.
Here authors aim to understand the 5-HT2AR coupling signature in response to different signaling probes and their physiological impacts using computational modeling, in vitro and in vivo experiments, and analysis of human brain tissue.
Breast cancer metastasis to the brain is rising in prevalence and is an increasingly lethal threat to the patients. Here, the authors show miR-199b-5p, secreted by some breast cancer cells and detected at a higher level in patients with brain metastases, impairs the metabolic coupling between neurons and astrocytes to facilitate development of brain metastasis.
The instability of perovskite solar cells hinders their commercialization. Here, authors report an industrially compatible strain-free encapsulation process based on lamination of highly viscoelastic semi-solid/highly viscous liquid encapsulant adhesive to reduce thermomechanical interfacial stress.
Resistance to glucocorticoids (GC) is a major obstacle for the treatment of pediatric B-cell acute lymphoblastic leukemia (B-ALL). Here, the authors report that GC-triggered CXCR4 internalization promotes a phospholipase C (PLC)-mediated cell survival pathway, driving GC resistance in B-ALL.
Human cervical mucosa and its interactions with the microbiome play a central role in female reproductive tract health and disease. Here, the authors develop physiological models of the human cervix using Organ-on-a-Chip technology that produce mucus, and respond to hormonal, environmental, and microbial cues similar to the living cervix.
Whether and how temporal interference (TI) stimulation disrupt primate oscillatory brain activity are not fully understood. Here authors show TI stimulation can non-invasively disrupt oscillatory brain activity but three factors make it too weak to impose new rhythms on the primate brain. Thus, it may be a potential method for safely controlling pathological brain activity.
Heterocycles, highly prized by the pharmaceutical industry, are often constructed from diazo compounds. Here, the authors report that direct photolysis of vinyldiazo compounds followed by [3+2]-cycloaddition gives access to these motifs.
Satellite data reveals a rise in multivariate extreme events in lakes since the 1980s, largely linked to agricultural practices and mean climatic warming.
Emperor penguins colony occupancy is variable and chiefly estimated with remote sensing images at end of the breeding season. Here, the authors provide a phenological model that can extrapolate occupancy from sparse data and can predict phenological events, breeding pairs and fledging chicks.
The evolution of the vertebrate head mesoderm involved the emergence of new structures and cell types. Here the authors generated a cell atlas of the cephalochordate neurula to study the origins of these novelties and propose a revised scenario for the evolution of the vertebrate head muscles.
Novel short-acting IL-22 bispecific biologics offer new hope for treating metabolic dysfunction-associated steatohepatitis (MASH), a global health concern with few treatment options. Here, the authors show these drugs significantly improve blood sugar control, liver fat, inflammation, and scarring.
While developmental phenotypes are often multigenic and involve environmental inputs, most research approaches involve perturbation of small numbers of genes. Here they use a synthetic evolution approach in Drosophila to show that adding extra copies of bicoid leads to rapid, system-wide phenotypic responses, potentiated by highly polygenic traits such as embryo size.