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Here authors aim to understand the 5-HT2AR coupling signature in response to different signaling probes and their physiological impacts using computational modeling, in vitro and in vivo experiments, and analysis of human brain tissue.
Breast cancer metastasis to the brain is rising in prevalence and is an increasingly lethal threat to the patients. Here, the authors show miR-199b-5p, secreted by some breast cancer cells and detected at a higher level in patients with brain metastases, impairs the metabolic coupling between neurons and astrocytes to facilitate development of brain metastasis.
The instability of perovskite solar cells hinders their commercialization. Here, authors report an industrially compatible strain-free encapsulation process based on lamination of highly viscoelastic semi-solid/highly viscous liquid encapsulant adhesive to reduce thermomechanical interfacial stress.
Resistance to glucocorticoids (GC) is a major obstacle for the treatment of pediatric B-cell acute lymphoblastic leukemia (B-ALL). Here, the authors report that GC-triggered CXCR4 internalization promotes a phospholipase C (PLC)-mediated cell survival pathway, driving GC resistance in B-ALL.
Emperor penguins colony occupancy is variable and chiefly estimated with remote sensing images at end of the breeding season. Here, the authors provide a phenological model that can extrapolate occupancy from sparse data and can predict phenological events, breeding pairs and fledging chicks.
The evolution of the vertebrate head mesoderm involved the emergence of new structures and cell types. Here the authors generated a cell atlas of the cephalochordate neurula to study the origins of these novelties and propose a revised scenario for the evolution of the vertebrate head muscles.
Novel short-acting IL-22 bispecific biologics offer new hope for treating metabolic dysfunction-associated steatohepatitis (MASH), a global health concern with few treatment options. Here, the authors show these drugs significantly improve blood sugar control, liver fat, inflammation, and scarring.
While developmental phenotypes are often multigenic and involve environmental inputs, most research approaches involve perturbation of small numbers of genes. Here they use a synthetic evolution approach in Drosophila to show that adding extra copies of bicoid leads to rapid, system-wide phenotypic responses, potentiated by highly polygenic traits such as embryo size.
In their study, Wang and Dagan show that 84% of antibiotic resistance genes in multidrug resistance plasmids in Escherichia, Salmonella, and Klebsiella reside within resistance islands that evolve within the framework of plasmid lineages.
Polygenic scores aggregate the effects of multiple genetic variants and can be used to predict disease risk. Here, the authors present a polygenic score method that incorporates non-additive inheritance modes (recessive, dominant, over-recessive, and over-dominant) and show that this can improve risk prediction for certain polygenic diseases.
Stomata function is essential for photosynthesis and the global carbon and oxygen cycles. Here, the authors report the regulatory framework that establishes rhythmic pore movements to prevent water loss at night and allow CO2 uptake during the day.
Porous materials with high strength are desirable for many applications. Here, the authors present a supramolecular metallic foam enabled by nanostructured liquid metals connected with high-density metal-ligand coordination to exhibit ultrahigh specific strength and recyclability.
IL-22RA1 is highly expressed on pancreatic islets and absent on immune cells. Here, the authors investigate its role by generating animals that lack IL-22RA1 on beta cells and reveal IL22RA1 signalling is critical for insulin biosynthesis and beta-cell health, evidenced by its regulation of MHC II expression and its suppressive effect on inflammation and cellular stress.
The transport behavior of high-entropy alloys (HEAs) remains unclear. Here, the authors explore the fundamentals of low-wear and high-conductivity refractory HEAs, examining the cocktail effect in conductivity, and highlight its potential applications in enhancing atomic-scale image resolution.
A freeform multimaterial assembly process (FMAP) is demonstrated, synchronizing laser induction with 3D printing for seamlessly integrating multimaterials into 3D objects, enabling streamlined, flexible, and precise electronic device fabrication.
Here, the authors develop Topo-seq to measure the DNA topology (∆Lk) restrained by individual nucleosomes in vivo. They show that nucleosome DNA topology is imprinted by its native chromatin context and persists when the nucleosome is relocated.
This paper unveils the complexity of human immune cell splicing, highlighting cell-specific isoforms and establishing connections between alternative splicing and complex traits. These findings have implications for understanding diseases and the evolution of the genome.