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Researchers have developed a noninvasive retina prosthesis based on ultrasound for treating blindness. This device uses ultrasound waves to stimulate the retina, creating artificial vision confirmed through behavior tests, offering a safer alternative to invasive treatments.
Efflux pumps confer antibiotic resistance by coupling proton import with drug export. In this work, the authors uncover the proton-coupled transport mechanism for the clinically relevant efflux pump NorA from the pathogenic bacterium S. aureus.
COVID-19 vaccines reduce the risk of severe disease in young people, but the absolute risk is low, and side effects have been reported. Here, the authors use data on 5–17 year olds in England to assess the overall risk-benefit profile of the vaccines.
Here the authors measure viral load in samples from skin lesions, saliva, oropharynx, and rectum of 77 patients with acute monkeypox virus infection as well as from environmental fomite swabs and show a high seropositivity rate for antibodies against A29L and H3L.
The uptake of gaseous elementary mercury by terrestrial vegetation in 2100 is likely to decrease by more than half compared to present-day conditions. This decrease is caused by the reduced stomatal conductance associated with increasing CO2 levels.
Kates et al. propose that nitrogen-fixing symbiosis between bacteria and angiosperms has been gained and lost multiple times, based on ancestral reconstructions of nodulation across a deeply sampled, 13,000-species phylogeny, in contrast to a single origin with many losses.
Incomplete proteolysis of amyloid-β (Aβ) peptides by γ-secretases is linked to Alzheimer’s disease. Using cryo-EM and functional analyses, this study uncovers the γ-secretase – Aβ46 structure and unveils key interactions for efficient Aβ cleavage.
The organization of top-down inputs in primary visual cortex (V1) remains unclear. Here the authors characterized corticocortical and thalamocortical top-down inputs recruiting V1 neurons with cell-type and layer-specificities, and revealed distinct forms of top-down input processing.
Here the authors show that Spa2 orchestrates adaptive actin remodelling in budding yeast by dynamically binding ADP-actin and inducing phase separation on F-actin, a crucial response to energy starvation.
Researchers demonstrate that image-processing metasurfaces can be dynamically reconfigured by using phase-change materials. The work might lead to novel tunable devices for compact optical computing for applications in AR/VR and bio-medical imaging.
This study demonstrates that future whole-soil warming has a much stronger effect on soil carbon emission in the alpine grassland ecosystem than what is estimated by previous warming experiments which only warm surface soils mostly.
PARP inhibitors (PARPi) have been approved for the treatment of metastatic triple-negative breast cancer (BC), however resistance and recurrence are often observed. Here, in preclinical models of BRCA1/2 wild type and homologous recombination competent BC, the authors show that C5aR1-positive tumor associated macrophages are associated with PARPi-resistance, suggesting targeting C5aR1 as a therapeutic option.
Maize demand in Sub-Saharan Africa is expected to increase. Here, the authors use data collected by One Acre Fund on 14,773 smallholder fields in the region and determine that maize production can be increased with minimal cropland expansion by improving management practices.
Intermittency is the behavior of extreme fluctuations observed in the flow of a fluid that is often associated with high Reynolds numbers. Here, the authors report intermittency in elastic turbulence at the low Reynolds number and high Deborah number limit.
Zero to ultralow-field NMR provides chemical information in the absence of a high magnetic field but it is difficult to measure molecules with quadrupolar nuclei due to their fast relaxation. This study examines zero-field J-spectra from isotopologues of ammonium cations, with quadrupolar nuclei, revealing the presence of a primary isotope effect of −58 mHz.
In this study, the authors employ metagenomics to explore the impact of environmental pollution on the human gut microbiome using samples from a cohort living in a very polluted area in Southern Italy, showing that pollutants degradation genes are more abundant in subjects with higher blood levels of those specific xenobiotics.
Bacterial-fungal interactions can stimulate the production of specialised microbial metabolites. Here, Richter et al. use co-culture experimental evolution to show that the presence of a fungus selects for increased surfactin production in the bacterium Bacillus subtilis, which inhibits fungal growth and facilitates the competitive success of the bacterium.
This study revealed an NF-YB1-SLRL2-bHLH144 regulatory module, centered on a key transcription factor SLRL2, that mediates the ABA-regulated amylose content in rice. Furthermore, SLRL2 is also involved in the regulation of rice dormancy
The researchers present an image sensor that allows every pixel to have independent exposure. It can sample a cell ROI’s fast fluorescence activity with long exposures at different phases, enhancing SNR and temporal resolution for capturing high-speed events.
Type I IFN is vital for antiviral defense. Here, the authors use TurboID-based proximity labeling to comprehensively map the protein landscapes surrounding core IFN signaling members. Among factors uncovered, PJA2 emerged as a negative regulator of IFN signaling that ubiquitinates the Janus kinases.