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For the carbonylation reactions to synthesize aldehyde, ester, amide, and other carbonyl derivatives, a transition metal-free and CO- free reaction was challenging but highly demanded. Here, the authors report a transition metal-free and CO- free method for deoxygenetive/denitrogenetive conversion of phenols and anilines to aldehydes and ketones.
A mitochondrial actin wave fragments mitochondria. Here, the authors find that the wave produces force that is resisted by mitochondrial tethering, inducing fission, with subsequent fusion promoting mitochondrial content mixing and mitochondrial homeostasis.
Common genetic variants can affect an individual’s immune response to pathogens. Here, the authors uncover and characterize variants regulating cytokine responses in Lyme Borreliosis in 1,060 patients.
Here, the authors demonstrate that mutations in the FG repeats of Nup98 significantly reduce its self-association capabilities and present a cryoEM structure exhibiting higher stability per residue then previously observed, suggesting spatial variations in self-association.
Improving mass transfer through hierarchically porous synthetic materials is a great challenge. Here the authors address this by expanding the original Murray’s law, a biomimetic principle defining the branching of veins in living structures.
Machine learning has not been strategically applied to design main-group catalysts. Here, the authors built an in-silico library of triarylboranes, which was used to identify reactive catalysts for functionalizing amino acids and peptides with H2.
Metabolic implications in AD are unclear. Here, authors found significant correlations between cognitive impairment and metabolic features in a Chinese aging cohort (n = 1397). The study highlights ammonia disturbance as a potential therapeutic target for AD.
Polarization reversal dynamics in sliding ferroelectrics is important for the application in slidetronics. Here, the authors observe the interlayer directional sliding induced polarization switching with simultaneous hysteresis response in γ-InSe:Y.
3D printing of functional gradients often requires specialized equipment and costly materials, constraining scalability. Here, using a conventional desktop FDM printer, authors present a 3D printing strategy using a filament that is itself 3D-printed to produce functional gradients.
Transparent roofs offer a solution for harnessing natural light in sustainable buildings. Here, authors demonstrate a polymer-based metamaterial with micro-pyramid surface structures that diffuses sunlight while offering passive cooling and self-cleaning properties.
The end of the green Sahara in the mid-Holocene was gradual, but punctuated by rapidly changing episodes of extreme drought and wetness, to which human societies were exposed and had to adapt to, as a lake record from southern Ethiopia suggests.
Here, the authors use passenger mutations to quantify expansion rate in ~6,000 people with mosaic chromosomal alterations in the NHLBI TOPMed cohort, finding associations between growth rate and blood counts along with germline genetic modulators of growth rate.
When countries phase out coal, they compensate affected companies, communities and workers. Today more than $200 billion are allocated for such payoff, but much larger amount will be needed if China and India also phase out coal to tackle climate change.
Previous measurements of FeSe0.45Te0.55 found one-dimensional (1D) defects that were interpretated as domain walls hosting propagating Majorana topological modes. Here, the authors reveal that these 1D defects correspond to sub-surface debris and show that the filling of the superconducting gap on these defects is topologically trivial.
Polypharmacology drugs are compounds designed to inhibit multiple protein targets. Here, authors use recent advances in AI to rapidly generate polypharmacology compounds against any pair of protein targets, experimentally validating numerous compounds targeting MEK1 and mTOR.
Arabidopsis α-Aurora kinase regulates plant cytokinesis by phosphorylating the microtubule-associated protein MAP65-3, which controls the dynamic organization of the phragmoplast structure essential for cytokinesis completion.
The assembly integrity of dimeric CRL3 E3 ligases are important in various physiological and pathological processes. Here, the authors show that an evolutionarily conserved CUL3 N-terminal motif contributes to both the assembly and activity of dimeric CRL3 E3 ligases.
Liquid Chromatography Mass Spectrometry (LC-MS) is a powerful method for profiling biological samples. Here, the authors have developed a suit of Batch Effect Removal Neural Networks (BERNN) to remove batch effects in large LC-MS experiments to maximize sample classification between conditions.
Here the authors structurally and mechanistically characterize the assembly of FADD, procaspase-8, and cFLIP through their death-effector domains (DEDs), providing insights into the regulation of apoptotic and necroptotic signalling.
In this study, the authors engineered a targeted Saccharomyces boulardii probiotic yeast platform, showing it exhibits high adherence to extracellular matrix proteins, resulting in longer gut residence, higher colon concentrations, and enhanced recovery in murine colitis.