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The researchers showcase an exciting surface metallic Dirac-vortex cavity design with enhanced power capabilities for electrically pumped Topological Lasers in the THz spectral range.
The noncovalent interaction of ammonium ion with multidentate oxygen-based host serving as a key reacting center in catalytic reactions is rare. In this work, the authors report a noncovalent interaction of ammonium ion enabled reactivity enhancement process, achieving the C–H functionalization of polyethylene glycols with acrylates.
Bacteria can use contractile injection systems, similar to viral tail structures, to deliver toxic proteins into other cells. Here, Nagakubo et al. identify a related system that modulates sporulation in multicellular Streptomyces bacteria.
To eliminate transport emissions by 2050, low carbon fuels must rapidly replace fossil fuels. The authors model these technological transitions for each transport mode and evaluate economy-wide tradeoffs of varied levels of transport decarbonization.
Some plants use nectar to attract ant bodyguards. Here, the authors use a cross-kingdom phylogenetic approach to find that ferns and angiosperms evolved nectaries in the Cretaceous, coinciding with ant evolution, and that ferns recruited ant-bodyguards from existing ant-angiosperm partnerships.
This study unveils that stop codon readthrough is prevalent in E. coli, particularly under stress conditions. It highlights the influence of stop codon type and genetic context, with both transcriptional and translational origins.
The authors study the [Nb/V/Ta] superconducting artificial superlattice, known to support a superconducting diode effect, by pulsed THz spectroscopy and simultaneous transport. They found a non-monotonic switching between the superconducting and normal state, which can be explained if the THz-driven vortex depinning determines the critical current.
Treatment failure following chimaeric antigen receptor (CAR) T cell therapy is common yet incompletely understood. In this study, the authors demonstrate that deletion of the mitochondrial negative regulator, MCJ, in CAR T cells promotes target cell killing ex vivo and augments their efficacy in an in vivo B cell leukaemia model.
Hydrogel fibres have potential in a range of applications such as flexible electronics, but achieving the desired mechanical properties can be challenging. Here, the authors report spider silk-inspired hydrogel fibres with tuneable mechanical properties suitable for flexible electronics.
Microbial migration profoundly impacts ecosystems. Here, the authors introduce a statistical approach to explore microbial dispersion following fecal microbiota transplant, uncovering dependencies between colonizing taxa, with insights into community dynamics.
Histone H2AX has a known role in DNA damage repair but interestingly, its loss is associated with resistance to poly(ADP-ribose) polymerase (PARP) inhibition in BRCA-deficient tumours. Here, the authors identify a role of γH2AX in the degradation of replication forks and demonstrate that H2AX loss drives PARP inhibitor resistance via increased stressed fork stability in BRCA-deficient tumours.
The authors report an inorganic tellurium-selenium-oxygen (TeSeO) alloyed semiconductor for high-mobility p-channel transistors and broadband photodetectors, through the scalable thermal evaporation method combined with post-oxygen implantation.
People learn by observing others and from personal experience, but which strategy they favor varies. Here, the authors show that while some people dynamically arbitrate and switch to the strategy that is most reliable, others preferentially use one or a fixed mixture of strategies.
Authors find that freestanding single crystalline antiferroelectric PbZrO3 membranes exhibit remarkable flexibility that can endure a maximum bending strain of 3.5%, with the assistance of mechanical-induced antiferroelectric-ferroelectric phase transition.
In this work, authors synthesize transparent radiative cooling cover windows for flexible and foldable electronic devices. Besides demonstrated enhanced mechanical and moisture-impermeable properties, these mitigate temperature rise of devices under solar irradiation and improve overall thermal management.
Striatal hyperactivity has been linked to compulsive behavior, but cell-type and pathway specific mechanisms are unclear. Here, the authors show excessive grooming in Sapap3-KO mice is associated with indirect pathway hyperactivity and suppression of hyperactivity normalizes grooming.
The Light Harvesting Complex Stress-Related Protein (LHCSR) can protect algae from severe photodamage via energy-dependent quenching (qE). Here, the authors find that a photoproduct of carotenoid S1 state is populated in qE and depopulated in 7.5 ps.
In the phase 2 study LCCC1520 (NCT02690558), clinical activity of pembrolizumab in combination with gemcitabine and cisplatin as neoadjuvant therapy in patients with muscle-invasive bladder cancer has been reported. Here the authors present molecular and immune cellular features associated with response to neoadjuvant chemo-immunotherapy.
Organic room temperature phosphorescent materials have useful properties, but development can be limited by processing and stability challenges. Here, the authors report a derivatisation strategy for the preparation of room temperature phosphorescent materials responsive to an electrostatic field.