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Authors find that freestanding single crystalline antiferroelectric PbZrO3 membranes exhibit remarkable flexibility that can endure a maximum bending strain of 3.5%, with the assistance of mechanical-induced antiferroelectric-ferroelectric phase transition.
Organic room temperature phosphorescent materials have useful properties, but development can be limited by processing and stability challenges. Here, the authors report a derivatisation strategy for the preparation of room temperature phosphorescent materials responsive to an electrostatic field.
Electron transfer in solids is a fundamental process in many functional nanomaterials. Here, the authors directly observe this process via x-ray crystallography for incorporating of electron-donor guest molecules in macrocyclic nanotube crystals.
The strong connection between the dynamics of a physical system and its Hamiltonian’s spectrum has scarcely been applied in the non-Hermitian case. Here, the authors use a photonic quantum walk to confirm and expand previous theoretical analyses connecting self-acceleration dynamics with non-trivial point-gap topology.
Controlled manipulation of cultured cells by delivery of exogenous macromolecules is a cornerstone of experimental biology. Here, the authors describe a platform to deliver defined numbers of macromolecules into cultured cell lines at single molecule resolution.
In this work, authors develop a high-efficiency micro-combined heat and power system powered by an opposed-piston engine which enables simultaneous generation of electricity and heating to residential homes or light commercial buildings. The design is shown to be particularly effective for colder climates.
Here, the authors discover the ground and excited state interlayer excitons in bi- and tri-layer 2H-MoSe2 crystals which exhibit electric-field-driven hybridisation with the intralayer A excitons, showing distinct spin, layer and valley characteristics.
Identifying modifiable risk factors that could prevent depression is important. Here, the authors show increased risks of incident depression in pre-frail and frail individuals and highlight the mediating role of brain structure and inflammation.
Sialin transports multiple substrates including sialic acid out of lysosomes, and neurotransmitters into synaptic vesicles. This study reports the cryo-EM structures of Sialin in multiple states revealing its transport and pH-sensing mechanisms.
Comprehensive single-cell metabolic profiling is critical for revealing phenotypic heterogeneity and elucidating the molecular mechanisms underlying biological processes. Here, the authors establish a novel single-cell metabolomics platform for in-depth organic mass cytometry.
How LGR4 impacts nutrition absorption and energy homeostasis is unknown. Here, the authors show that LGR4 loss in the intestinal epithelium decreases the proportion of enterocytes selective for long-chain fatty acid absorption, reducing lipid absorption and improving lipid and glucose metabolism.
GPCRs can form functionally important dimers. Here, authors study impact of dimerization of the secretin receptor on peptide ligand binding and show high receptor conformational dynamics that facilitate G protein recruitment and activation.
Topological flat bands offer a solid-state platform for studying the interplay between topology and electron correlations. Here, the authors demonstrate that a prototypical 3D Dirac material can host topological flat bands under magnetic fields due to polar-distortion-assisted Rashba splitting.
Myeloid cell populations play a critical role in lung cancer progression. Here, the authors use scRNA-seq and spatial transcriptomics to identify changes in the phenotype of macrophages within the tumour microenvironment.
Alkylsulfonic acids represent an alternative source of sulfur for the origins of life. Here the authors demonstrate, via laboratory simulation experiments, the formation of these compounds in interstellar analog ices with implications for their incorporation into asteroids such as Ryugu.
Tubulointerstitial inflammation occurs frequently in acute kidney injury (AKI), and Mφ autophagy is a known contributor to inflammation-related diseases. Here, Yuan et al. show that Mφ autophagy deficiency induces systemic inflammation, impairs mitochondria, and worsens kidney injury in AKI mice.
Amplification of glucose stimulated insulin secretion by lipids is not fully understood due to complex inter organ communication in glycemic regulation. Here the authors show Vaha, a Drosophila lipase synthesized in the gut, concentrates in insulin producing cells in the brain to regulate insulin like peptide release.