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The preparation of C − N axially chiral compounds, a class of privileged scaffolds in pharmaceuticals, advanced materials and organic synthesis, has recently attracted significant interest. Herein the authors report a chiral dinitrogen ligand promoted asymmetric Catellani reaction for the synthesis of C–N axially chiral scaffolds.
The robust anion framework of ionic nanocrystals impedes shape change by cation exchange. Here, the authors report an anisotropic, regenerative transformation of Cu1.8S nanoplates during cation exchange.
Recently, studies have identified different low-density lipoprotein receptors as functional entry receptors for alphaviruses. In this Perspective, the authors compare the known alphavirus-receptor structures and discuss why it might be challenging to generate a broad-spectrum entry inhibitor.
Synthetic biology applications require finely tuned gene expression, often mediated by synthetic transcription factors. Here the authors validate two plant-derived proteins, FHY1 and FHL, acting as transactivators in mammalian cells for orthogonal, modular, and tunable control of gene transcription by forming a photosensing transcriptional regulation complex with PhyA.
While synthetic active matter research has concentrated on developing point-like, interacting entities, designing freely jointed active assemblies from autonomously powered components has remained a challenge. Here, the authors introduce freely jointed active polymers created from self-propelled droplets, uncovering emergent rigidity and propulsion, thereby advancing towards self-morphic synthetic materials.
Informal transportation services constitute the primary form of public transport in the Global South. Here, the authors analyze the structure of route networks in cities across the globe, showing how informal routes self-organize into consistent line services that often outperform centralized services in the Global North, exhibiting fewer detours and comparable interconnectivity.
By performing a tissue-specific transcriptome analysis, Zhang et al. show how age-related loss of germline stem/progenitor cells in C. elegans is regulated by a signal produced by non-niche cells within the same organ system.
To identify intracellular dynamics at the single-cell level, authors develop a scalable method via a divide-and-conquer strategy and apply it to a yeast transcription system. The results underscore the heterogeneity in isogenic cells, which is validated by a noise-decomposition method.
Developing artificial leaves is crucial for advancing Net Zero Future, but most artificial leaves rely on the use of metal or semiconductors catalysts that usually have a lower catalytic activity and selectivity compared to biocatalysts. Here the AUs report Ecoleaf, a biodegradable artificial leaf that mimics the controlled expansion and contraction of stomata and enables enzymic CO2 conversion.
Biological computing is a promising field with potential applications in biosafety, environmental monitoring, and personalized medicine. Here the authors create bio-computers using engineered E. coli colonies that respond to chemical gradients, producing different logic functions depending on how they are spatially arranged.
The scalable fabrication of wide-bandgap perovskites in air remains challenging due to moisture-induced degradation of perovskites. Here, authors utilize low polarity and moderately volatile n-butanol to enhance film uniformity, achieving efficiency of 29.4% for double-sided textured tandem cells.
The Legionella collagen-like protein (Lcl) is important for host adhesion in Legionella pneumophila. Here, the authors provide structural and biochemical data, which provides insights into a distinct “fuzzy” glycosaminoglycan binding mechanism.
This study reports the genomics- and metabolomics-guided discovery of aminovinyl-(methyl-)cysteine-containing peptides (ACyP). One of these peptides, massatide A, demonstrates excellent activity against drug-resistant gram-positive pathogens.
Here, the authors develop a microfabrication method to realize the optical observation of quantum coherence and interference of a single moiré exciton in twisted semiconducting heterobilayers of transition metal dichalcogenides, persisting beyond 10 ps.
Hydrogels capable of swift mechanical energy dissipation are desirable for various uses, but traditional energy absorption in hydrogels typically relies on viscoelastic mechanisms and often suffers from slow recovery. Here, the authors report a hydrogel design harnessing molecular friction to achieve efficient energy dissipation and rapid recovery.
Tobacco smoking is an important risk factor for lung cancer. Here the authors report that tobacco carcinogens promote metabolic syndrome and metabolic reprogramming of macrophages, associated with lung cancer progression in preclinical models.
The realization of intrinsically stretchable organic photovoltaics with excellent mechanical robustness remains challenging. Here, the authors redistribute the strain in the active layer to PEDOT:PSS electrodes with simultaneously enhanced stretchability and interfacial adhesion in the device.
Superoxide dismutase 3 is elevated in patients and animals infected by protozoan parasites such as Plasmodium. Here, Li et al. show that SOD3 expression is associated with experimental cerebral malaria and inhibition of host immune responses.
Excitation energy transfer is important for many photoinduced biological processes in systems with multiple chromophores. Here, the authors elucidate this process for the coenzyme NADH using ultrafast spectroscopy and quantum dynamics.
Efficient base editors for direct thymine (T) editing are highly desirable. Here, authors develop two deaminase-free glycosylase-based base editors for direct T editing (gTBE) and C editing (gCBE) by rounds of structure-informed mutagenesis on human DNA glycosylase UNG and further engineering.