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Biaryl compounds with an axial chirality are valuable architectures but few methods have been developed for the construction of bridged biaryls, a subclass of these compounds that bear a tether to connect the two arenes and form a medium-sized ring. Here, the authors design a Co/SPDO-catalyzed aerobic oxidative coupling/desymmetrization sequence of prochiral phenols for the enantioselective synthesis of biaxial bridged m-terphenyls embedded in an azocane.
The 2021 Pacific Northwest Heatwave challenged standard attribution methods. The authors use a weather model that predicted the event to quantify human impact on the heat, suggesting that such models could be used broadly to assess changing weather risk.
A comprehensive understanding of the transient characteristics in solid oxide cells is crucial when integrated with intermittent renewable energy. Here, authors reveal expressions for two general characteristic times quantifying transient phenomena due to heat and mass transfer lags in SOCs.
Human HtrA2 plays an important part in the cellular protein quality control system. Here, advanced NMR spectroscopy unravels the initial activation steps of HtrA2 upon activating peptide binding and the mechanistic role of divalent cations.
Interleukin-33 (IL-33) is a master initiator of cancer-prone chronic inflammation. Here, the authors show that TLR3/4-TBK1-IRF3 pathway activation induces IL-33, and the cholesterol-lowering drug, statin, blocks this pathway to suppress chronic inflammation and its cancer sequela.
The immunosuppressive tumour microenvironment in Nasopharyngeal carcinoma (NPC) is a cause of low efficacy of immunotherapies in these tumours. In this study, the authors delineate a FLI1-mediated Kyn metabolic mechanism as an immune evasion mechanism in NPC and they show that pharmacological inhibition of FLI1 improves both spontaneous and checkpoint therapy-induced immune responses.
The study identified and structurally characterized the UDP-glycosyltransferases (UGTs) responsible for regioselective glycosylation of wolfberry-derived bioactive lycibarbarspermidines, elucidating the molecular basis for their substrate specificity.
This work reveals the presence of the photonic Hall effect and photonic magnetoresistance in a field-dependent random laser. This observation visualizes the influence of magnetic field on random lasers scattering at the microscopic level.
The authors observe THz emission from Ni/Pt heterostructure due to long-range ballistic orbital transport. The velocity of orbital current can be optically tuned by laser fluence, opening the avenue for future optorbitronic devices.
Recent seismological studies challenge the traditional view that the interface between the core and mantle is a straightforward discontinuity. As seismology is pushed to its observational limits, a complex - potentially compositionally layered - region between the core and mantle is emerging.
Chirality has long fascinated chemists, but asymmetric synthesis has largely focused on central, axial, and helical chirality to date. Here, the authors synthesize dianthranilides with planar chirality, via cinchona alkaloid-catalyzed (dynamic) kinetic resolution.
By resonant pumping the organic cation in 2D perovskite, Fu et al. report the electronic and mechanical couplings between the organic and inorganic sublattices, evidenced by the reduced bandgap and modified lattice degree of freedom within the inorganic sublattice, and slow heat transfer process.
Phosphanorcaradienes can serve as synthons for transient phosphinidene but the synthesis remains challenging. Here, the authors report a synthesis protocol for a phosphanorcaradiene, in which one of the benzene rings is intramolecularly dearomatized through attachment to the phosphorus atom.
Intestinal mucus consists of densely O-glycosylated mucins, serving as a nutrient source for bacteria. Elzinga et al. show that mucin-degrading Akkermansia muciniphila selectively binds to O-glycan structures found on human colonic mucins.
The authors report experimental evidence of phonon Stark effect in 2H-MoS2 bilayers. A Stark phonon appears as the interlayer excitons are tuned to resonate with the LA phonon emission line, and shows a linear energy shift upon application of an out-of-plane electric field.
Here authors aim to understand the 5-HT2AR coupling signature in response to different signaling probes and their physiological impacts using computational modeling, in vitro and in vivo experiments, and analysis of human brain tissue.