Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Under a high emission scenario, strong positive Indian Ocean Dipole events pre-2100 are projected to increase, opposite to moderate events. The authors show a post-2100 decrease in strong and moderate events, highlighting a nonlinear response to global warming.
Genetic testing is crucial for precision cancer medicine. Here, the authors develop a one-pot ERA-CRISPR assay to detect variable same-site indels, using an engineered AsCas12a variant with improved mismatch tolerance and broadened PAM scope.
Pathogenic bacteria produce cholesterol-dependent cytolysins to form pores in eukaryotic membranes. Here, the authors show that human gut bacteria use a related family of pore-forming toxins for intra- and interspecies antagonism.
The authors find a nonlinear, multiyear-long and country-heterogeneous economic loss induced by the Indian Ocean Dipole. Under a high emission scenario, the amplitude of the dipole is increasing, causing additional financial losses in the 21st century.
Here the authors present a framework for estimating disease risk using PGS accounting for country, age and sex. They find that PGSs have a significant sex-specific effect on common diseases, and their effect is typically larger in young individuals.
Site-directed insertion is a powerful approach for generating mutant lines but, historically, technically challenging. Here, the authors demonstrate CRIMP, an optimised protocol and universal toolkit (CRIMPkit), to greatly improve the efficacy of generating and studying mutant lines.
Ferroptosis is of great importance in plant immunity including microbe-plant interactions. Here, the authors unveil that a regulated ferroptosis process is involved in the mutualistic symbiosis and disease resistance of endophyte OsiSh-2 and host rice.
Mass spectrometry imaging (MSI) is often limited by low spatial resolution. Here, the authors propose Gel-Assisted Mass Spectrometry Imaging (GAMSI), which enhances the spatial resolution of MALDI-MSI monitoring of lipids and proteins to the sub-micrometre level without changing existing hardware setups.
Theory predicts that adaptive mutations can have indirect negative effects on fitness. This study demonstrates how ‘adaptation begets adaptation’: changes to the sociogenetic environment accompanying rapid adaptation in wild crickets provoked genome-wide compensatory adaptation.
Titanium has a strong affinity to oxygen, resulting in an increase in the manufacturing cost and complexity of the processes. Here the authors introduce a high-throughput technique using yttrium that can reduce the oxygen content in molten titanium to the level suitable for structural applications.
Ubiquitin system factors are critical regulators of DNA repair pathways. Through a functional genetic screen, the authors identify a novel role of ubiquitin-conjugating enzyme UBE2D3 in promoting DNA repair at deprotected telomeres by limiting the accumulation of RNF168 and promoting ample ATM-dependent phosphorylation of KAP1.
Primary human hepatocyte (PHH) transplantation could be an alternative to liver transplantation. Here, the authors use the mRNA-LNP platform to express growth factors in the liver in a controlled manner to drastically improve PHH engraftment, thus, reducing disease burden and enhancing overall liver function.
Recent studies reported evidence of a new phase in the kagome metal CsV3Sb5 between the charge density wave and superconducting transitions. Here the authors reveal symmetry properties of this phase in CsV3Sb5 thin flakes probed by in-plane magnetotransport, suggesting a 3D orbital current order.
The control of atomically precise etching of nano-sized metal clusters is important for understanding their structure-specific properties. Here, the authors report the etching of a single gold atom on a hypercarbon centre of gold(I) clusters.
Strong air-sea interactions during atmospheric rivers often lead to modest upper ocean heat changes. The authors show that interior ocean dynamics are compensating for these air-sea exchanges. These findings can help improve subseasonal forecasts.
Cryptophytes are ancestral photosynthetic organisms. Here the authors report the cryo-EM structure of the PSII–ACPII from the cryptophyte Chroomonas placoidea, showing that cryptophyte PSII–ACPII consists of a PSII dimer and twelve ACPII monomers that are organised into four linear trimers.
Understanding the intricate relationship between alloying elements and oxidation processes is essential for the integrity and performance of materials. Here, the authors study the effects of atomic size and redox potential to understand the oxidation process and structural changes in surface oxides.
Transonic buffet is a ubiquitous challenge in commercial aviation since it can result in catastrophic structural failure of the aircraft wings. Here, authors experimentally show that this critical aerodynamic phenomenon can be mitigated using a carefully designed porous trailing edge on the wing.
Multiple doping and low concentration of long-wavelength emitters suffer from repeatability and stability. Here, authors report singly-doped cluster-based white light-emitting system at high doping concentration of 30%, and optimize the charge and energy transfer based on antenna effect of ligands.