Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
A freeform multimaterial assembly process (FMAP) is demonstrated, synchronizing laser induction with 3D printing for seamlessly integrating multimaterials into 3D objects, enabling streamlined, flexible, and precise electronic device fabrication.
Here, the authors develop Topo-seq to measure the DNA topology (∆Lk) restrained by individual nucleosomes in vivo. They show that nucleosome DNA topology is imprinted by its native chromatin context and persists when the nucleosome is relocated.
This paper unveils the complexity of human immune cell splicing, highlighting cell-specific isoforms and establishing connections between alternative splicing and complex traits. These findings have implications for understanding diseases and the evolution of the genome.
Research on the Kit locus shows TAD boundary deletion may or may not trigger ectopic gene activation in different cell types, influenced by active enhancers’ position relative gene promoters.
According to conventional wisdom, angle-resolved photoemission spectroscopy (ARPES) can only measure the magnitude of the superconducting gap but not its phase. Here, the authors propose a new method to directly detect the superconducting gap phase using ARPES and validate this technique on a cuprate superconductor.
Here the authors report the AI system Umol that predicts flexible all-atom structures of protein-ligand complexes from sequence information, advancing AI-driven drug discovery: accurate structures and affinity can be selected from predicted confidence metrics (plDDT).
Luminescent materials with narrowband emissions are vital for optoelectronic applications. Here, the authors achieve room temperature phosphorescence with a FWHM of 30 nm through the multiple resonance effect and showcase its practical application in X-ray imaging.
The specificity of protein deubiquitination relies on deubiquitinase-substrate interactions (DSIs). Here, authors leverage evolutionary information from the proteome to predict DSIs, even with an inadequate training dataset.
Membrane fusion is crucial for fabricating artificial membranes. Here, the authors present an approach combining electric field with hydraulic pressure to physically control the fusion, enabling tuning of the shape and size of the 3D freestanding lipid bilayers in physiological solutions.
Here, using a dynamic modelling approach, the authors find that the spread of dengue through Mexico and Brazil is shaped by specific interactions between human mobility, climate, and the environment. Their models can also be applied to predict future spread in these geographic areas.
Genetic variants in the SBNO2 locus are associated with Crohns’s disease. Here the authors show that those variants cause a cell type and isoform specific effect were transcription of SBNO2 isoform 2 impacts on antimicrobial activity in macrophages providing a plausible gene-mechanism-phenotype model.
Biohydrogen production technologies effectively use waste biomass resources and produce high-purity hydrogen. Here, authors present and evaluate a continuous pilot-scale biohydrogen production system based on spectrum coupling, thermal effect, and multiphase flow properties of hydrogen production.
A single exometabolite produced by an opportunistic bacterial pathogen of the root microbiome enhances host susceptibility to salt stress and promotes plant disease in complex soil systems.
Harnessing the potential of considerable food security efforts requires the ability to translate them into commercial applications. In this Perspective, the author explores the alternative protein source start-up landscape.
The authors report structure of PSII-ACPII from a cryptophyte alga Chroomonas placoidea, providing insights into a distinct supramolecular organization and assembly of antennas in the supercomplex and possible excitation energy transfer pathways.
Birds vary in body mass by many orders of magnitude, but how this effects the evolution of their skeletal proportions is unclear. This study shows that small body size is associated with decreased evolutionary integration between wing bone sizes, facilitating increased evolutionary lability.
This study shows that Crimean-Congo hemorrhagic fever virus (CCHFV) recruits apoE, an exchangeable apolipoprotein that mediates LDL/LDL-R interaction, to promote virion entry via the LDLR. Molecules that down-regulate LDL-R inhibit CCHFV infection.