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The predatory bacterium Bdellovibrio exovorus attaches on the surface on other bacteria and feeds on them. Here, the authors study the lifecycle of B. exovorus, showing that it proliferates by non-binary division, firm junctions are established between prey and predator outer membranes, and a proteinaceous S-layer does not protect prey cells against predation.
Many cyclic dipeptide natural products can be modified by cyclodipeptide oxidase enzymes. Here, the authors report the structural characterization of the cyclodipeptide oxidase AlbAB and show that it assembles into heterooligomeric enzyme filaments.
Fragile X syndrome is a neurodevelopmental disorder with altered neuronal excitability and behavior. Here, the authors show that dysfunction of astroglial Kir4.1 potassium channels drives neuronal and behavioral impairments in a fragile X mouse model.
The authors present a 3D determination of the ferroelectric domain structure in a hexagonal yttrium manganite nanocrystal using multi-peak Bragg coherent x-ray diffraction imaging and reconstructing the full displacement field and strain tensor
Single-cell RNA sequencing data analysis is limited by noise and high dimensionality. Here, authors present scLENS, a tool that automates accurate signal detection without manual input, particularly in complex datasets.
Initially anode-free batteries with garnet-type solid-state electrolytes suffer from internal strain by repeated Li plating/stripping. Here, the authors propose a near-strain-free anode architecture for interfacial diffusion of Li metal that suppresses volume expansion during cycling.
The large intestine mucosa possesses a surprising plasticity to switch on small intestine genes. Here, Wei G. et al. show that a chromatin complex composed of SATB2, MTA2 and HNF4A regulates this tissue plasticity in the adult gut.
The safety profile of proton pump inhibitor (PPI) use remains controversial. Here, the authors show that PPI use is associated with an increased risk of 15 leading global diseases, with absolute risks increasing with baseline risks, highlighting the need for personalized PPI use strategies.
This study provides evidence for long-term effects of volcanic emissions of large quantities of gaseous mercury (Hg) and plant mutagenesis by recording high abundances of malformed fern spores across the Triassic-Jurassic boundary and Early Jurassic.
In most materials, the hall conductivity has a scaling to the longitudinal resistance that varies between linear and quadratic. Here, Zhang et al demonstrate a hall conductivity proportional to the fifth power of the longitudinal conductivity in Mn3Si2Te6, which they attribute to enhanced force on charge carriers due to chiral orbital currents.
MCM8-9 and HROB function together in DNA damage response. Here, the authors describe the mechanism of DNA unwinding by MCM8-9 and its activation by HROB. HROB makes direct contacts with both MCM8 and MCM9 and promotes DNA unwinding downstream of MCM8-9 loading and hexameric ring formation on DNA.
Eye tracking techniques enable high-efficient, natural, and effortless human-machine interaction. Here, Zhu et al. proposed a contact lens to track eye movement for wireless eye-machine interaction
Paralog synthetic lethals have been assessed with multiple CRISPR-based methods, but systematic comparison among these platforms is unavailable. Here, the authors systematically compare combinatorial perturbation platforms and establish the in4mer CRISPR/Cas12a multiplex knockout platform.
In neural progenitor cells, recurrent DNA break clusters (RDCs) occur to genes crucial for brain function. Here the authors find that most RDCs emerge at long-traveling unidirectional replication forks, and often unrelated to R-loops.
The work proposes the concept of distinct micro-habitats within an intact soil matrix and describes composition and metabolic pathways of their bacterial inhabitants, as a first step towards a generalizable C processing-focused classification of soil micro-environmental conditions.
Achieving supported nanoclusters with unique geometric and electronic structures continues to pose a challenge. Here, the authors introduce a plasma-assisted treatment approach for generating supported metal oxide nanoclusters, facilitated by the rapid transformation of monomeric dispersed metal oxides.
A major challenge for spin-based information technologies is the generation of spin polarization in otherwise nonmagnetic materials. Here, Arnoldi et al. demonstrate how ultrafast laser excitations can be used to generate spin polarization in a fullerene/tungsten diselenide heterostructure.
Mastomys natalensis is a rodent species native to West Africa that is the primary reservoir host for Lassa virus. Here, the authors investigate whether the invasive rodent Rattus rattus decreases M. natalensis density and could therefore indirectly decrease zoonotic transmission of Lassa virus to humans.
An inflammatory-fibrotic tumor microenvironment supports metastatic disease progression in pancreatic ductal adenocarcinoma (PDAC). Here the authors show that metastasis-infiltrating macrophages influence metastasis-associated fibroblast (MAF) heterogeneity in liver metastatic PDAC, by promoting JAK/STAT signalling pathway activation in MAFs.
Organic room temperature phosphorescence (RTP) is limited to rigid environments. Here, the authors report a single-component system with robust persistent RTP emissions in various aggregation states, such as crystalline, fine powder, and amorphous.