Heterocycles such as thiazoles are introduced into ribosomally synthesized peptide metabolites by post-translational modification. The enzyme that installs those rings has been identified, providing insight into heterocyclization biochemistry and the potential capabilities of an entire protein family.
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Kelly, W. Ringing in a new view. Nat Chem Biol 8, 505–507 (2012). https://doi.org/10.1038/nchembio.973
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DOI: https://doi.org/10.1038/nchembio.973
