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Molecular recognition

O-GlcNAc transfer: size matters

O-GlcNAc transferase is an essential protein catalyzing the O-GlcNAc modification of hundreds of intracellular proteins in higher eukaryotes. The structure of human O-GlcNAc transferase represents a leap in our understanding of the catalytic mechanism and recognition of protein substrates.

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Figure 1: Insights into the human OGT structure.

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Correspondence to Daan M F van Aalten.

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Gay, L., Zheng, X. & van Aalten, D. O-GlcNAc transfer: size matters. Nat Chem Biol 7, 134–135 (2011). https://doi.org/10.1038/nchembio.529

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