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Commentary

Nature Chemical Biology 5, 441–447 (1 July 2009) | doi:10.1038/nchembio0709-441

A crowdsourcing evaluation of the NIH chemical probes

Tudor I Oprea , Cristian G Bologa , Scott Boyer , Ramona F Curpan , Robert C Glen , Andrew L Hopkins , Christopher A Lipinski , Garland R Marshall , Yvonne C Martin , Liliana Ostopovici-Halip , Gilbert Rishton , Oleg Ursu , Roy J Vaz , Chris Waller , Herbert Waldmann & Larry A Sklar

Between 2004 and 2008, the US National Institutes of Health Molecular Libraries and Imaging initiative pilot phase funded 10 high-throughput screening centers, resulting in the deposition of 691 assays into PubChem and the nomination of 64 chemical probes. We crowdsourced the Molecular Libraries and Imaging initiative output to 11 experts, who expressed medium or high levels of confidence in 48 of these 64 probes.