Brief Communication abstract
Nature Chemical Biology 5, 462 - 464 (2009)
Published online: 17 May 2009 | Corrected online: 18 August 2009 | doi:10.1038/nchembio.177
There is a Corrigendum (September 2009) associated with this Brief Communication.
Chromatin-level regulation of biosynthetic gene clusters
Jin Woo Bok1,9, Yi-Ming Chiang2,3,9, Edyta Szewczyk4,8, Yazmid Reyes-Dominguez5, Ashley D Davidson4, James F Sanchez3, Hsien-Chun Lo3, Kenji Watanabe3, Joseph Strauss5, Berl R Oakley4,8, Clay C C Wang3,6 & Nancy P Keller1,7
Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B. Modification of the chromatin landscape in fungal secondary metabolite clusters allows for a simple technological means to express silent fungal secondary metabolite gene clusters.
- Department of Medical Microbiology and Immunology (formerly Department of Plant Pathology), University of Wisconsin-Madison, Madison, Wisconsin, USA.
- Graduate Institute of Pharmaceutical Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan, ROC.
- Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California, USA.
- Department of Molecular Genetics, Ohio State University, Columbus, Ohio, USA.
- Fungal Genomics Unit, Austrian Research Centers and BOKU University Vienna, Vienna, Austria.
- Department of Chemistry, University of Southern California, Los Angeles, California, USA.
- Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
- Present addresses: Research Center for Infectious Diseases, Würzburg, Germany (E.S.), and Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA (B.R.O.).
- These authors contributed equally to this work.
Correspondence to: Clay C C Wang3,6 e-mail: clayw@usc.edu
Correspondence to: Nancy P Keller1,7 e-mail: npkeller@wisc.edu
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