Brief Communication abstract
Nature Chemical Biology 5, 459 - 461 (2009)
Published online: 26 April 2009 | doi:10.1038/nchembio.174
Green fluorescent proteins are light-induced electron donors
Alexey M Bogdanov1, Alexander S Mishin1, Ilia V Yampolsky1, Vsevolod V Belousov1, Dmitriy M Chudakov1, Fedor V Subach2, Vladislav V Verkhusha2, Sergey Lukyanov1 & Konstantin A Lukyanov1
Proteins of the green fluorescent protein (GFP) family are well known owing to their unique biochemistry and extensive use as in vivo markers. We discovered that GFPs of diverse origins can act as light-induced electron donors in photochemical reactions with various electron acceptors, including biologically relevant ones. Moreover, via green-to-red GFP photoconversion, this process can be observed in living cells without additional treatment.
- Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
- Department of Anatomy and Structural Biology, and Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Correspondence to: Konstantin A Lukyanov1 e-mail: kluk@ibch.ru
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