Efficient transport by single two-headed motor proteins requires coordination of the motor domains. A new single-molecule study sheds light on an important coordination mechanism by demonstrating an asymmetric strain dependence of the weak-to-strong binding transition in myosin-VI heads.
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References
Vale, R.D. Cell 112, 467–480 (2003).
Iwaki, M., Iwane, A.H., Shimokawa, T., Cooke, R. & Yanagida, T. Nat. Chem. Biol. 5, 403–405 (2009).
Sweeney, H.L. & Houdusse, A. Curr. Opin. Cell Biol. 19, 57–66 (2007).
Altman, D., Goswami, D., Hasson, T., Spudich, J.A. & Mayor, S. PLoS Biol. 5, e210 (2007).
Ali, M. et al. Biophys. J. 86, 3804–3810 (2004).
Huxley, A.F. Prog. Biophys. Biophys. Chem. 7, 255–318 (1957).
Yildiz, A. et al. J. Biol. Chem. 279, 37223–37226 (2004).
Ali, M.Y. et al. Proc. Natl. Acad. Sci. USA 104, 4332–4336 (2007).
De La Cruz, E.M., Ostap, E.M. & Sweeney, H.L. J. Biol. Chem. 276, 32373–32381 (2001).
Altman, D., Sweeney, H.L. & Spudich, J.A. Cell 116, 737–749 (2004).
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Lindén, M. Pulling out the coordination mechanism of myosin-VI. Nat Chem Biol 5, 376–377 (2009). https://doi.org/10.1038/nchembio0609-376
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DOI: https://doi.org/10.1038/nchembio0609-376
