Synthetic agonists of sphingosine-1-phosphate receptor subtype 1 are able to generate long-term signaling that persists for hours after ligand-induced receptor internalization. These signals are independent of agonist potency, can be reversed after receptor internalization by specific antagonists, and show a distinct acyl-chain-length structure-activity relationship.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Change history
13 November 2009
In the version of this article initially published, the chemical structures for AFD-R, FTY720-P and OC5 were incorrect. The error has been corrected in the HTML and PDF versions of the article.
References
Mullershausen, F. et al. Nat. Chem. Biol. 5, 428–434 (2009).
Mandala, S. et al. Science 296, 346–349 (2002).
Gräler, M.H. & Goetzl, E.J. FASEB J. 18, 551–553 (2004).
Matloubian, M. et al. Nature 427, 355–360 (2004).
Jo, E. et al. Chem. Biol. 12, 703–715 (2005).
Sanna, M.G. et al. Nat. Chem. Biol. 2, 434–441 (2006).
Foss, F.W. Jr . et al. Bioorg. Med. Chem. 15, 663–677 (2007).
Gonzalez-Cabrera, P.J., Hla, T. & Rosen, H. J. Biol. Chem. 282, 7254–7264 (2007).
Oo, M.L. et al. J. Biol. Chem. 282, 9082–9089 (2007).
Schürer, S.C. et al. ACS Chem. Biol. 3, 486–498 (2008).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cahalan, S., Rosen, H. S1P1 signaling just keeps going and going and going.... Nat Chem Biol 5, 377–378 (2009). https://doi.org/10.1038/nchembio0609-377
Issue Date:
DOI: https://doi.org/10.1038/nchembio0609-377
This article is cited by
-
Erratum: S1P1 signaling just keeps going and going and going...
Nature Chemical Biology (2009)