In the realm of modern drug discovery technologies, fragment-based approaches and virtual ligand screening are emerging alternative approaches to high-throughput screening (HTS). For as simple as it sounds, a hybrid approach in which fragments are discovered first in silico may be an unbeatable route to hit identification for some drug targets.
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Katie Vicari
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Pellecchia, M. Fragment-based drug discovery takes a virtual turn. Nat Chem Biol 5, 274–275 (2009). https://doi.org/10.1038/nchembio0509-274
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DOI: https://doi.org/10.1038/nchembio0509-274
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