Exposure to zinc can cause pain and inflammation and can be harmful to human health. New evidence suggests that activation of the irritant receptor, TRPA1, which is expressed on pain-sensing neurons, may be responsible for some of these symptoms of zinc toxicity.
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The authors are employees of Johnson & Johnson Pharmaceutical Research and Development, LLC, which has conducted research relating to TRPA1.
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Banke, T., Wickenden, A. Intracellular zinc irritates TRPA1. Nat Chem Biol 5, 141–142 (2009). https://doi.org/10.1038/nchembio0309-141
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DOI: https://doi.org/10.1038/nchembio0309-141
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