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Alkaloid biosynthesis takes root

Engineered biosynthesis of modified natural products normally uses microbes as biochemical factories. Now, chemical biologists are taking advantage of the largely untapped biochemical potential of plants.

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Figure 1: Hairy roots of Madagascar periwinkle transformed with the V214M strictosidine synthase produce modified monoterpene indole alkaloid natural products.

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Ryan, K., Moore, B. Alkaloid biosynthesis takes root. Nat Chem Biol 5, 140–141 (2009). https://doi.org/10.1038/nchembio0309-140

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  • DOI: https://doi.org/10.1038/nchembio0309-140

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