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PKR and the ribosome compete for mRNA

Nature Chemical Biology volume 5, pages 873–874 (2009)Cite this article

The RNA-activated protein kinase PKR inhibits translation initiation by sensing long viral double-stranded RNA. A new report indicates that PKR is also activated by a cellular mRNA, but only when ribosomes are not initiating translation.

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Figure 1: Model for regulating translation by IFN-γ mRNA.

References

  1. Lee, F. & Yanofsky, C. Proc. Natl. Acad. Sci. USA 74, 4365–4369 (1977).

    Article  CAS  Google Scholar 

  2. Babitzke, P. & Yanofsky, C. Proc. Natl. Acad. Sci. USA 90, 133–137 (1993).

    Article  CAS  Google Scholar 

  3. Winkler, W.C. & Breaker, R.R. ChemBioChem 4, 1024–1032 (2003).

    Article  CAS  Google Scholar 

  4. Henkin, T.M. Genes Dev. 22, 3383–3390 (2008).

    Article  CAS  Google Scholar 

  5. Nudler, E. & Mironov, A.S. Trends Biochem. Sci. 29, 11–17 (2004).

    Article  CAS  Google Scholar 

  6. Cohen-Chalamish, S. et al. Nat. Chem. Biol. 5, 896–903 (2009).

    Article  CAS  Google Scholar 

  7. Balachandran, S. et al. Immunity 13, 129–141 (2000).

    Article  CAS  Google Scholar 

  8. Garcia, M.A. et al. Microbiol. Mol. Biol. Rev. 70, 1032–1060 (2006).

    Article  CAS  Google Scholar 

  9. Yueh, A. & Schneider, R.J. Genes Dev. 10, 1557–1567 (1996).

    Article  CAS  Google Scholar 

  10. Holbrook, S.R. Curr. Opin. Struct. Biol. 15, 302–308 (2005).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Rebecca Toroney and Philip C. Bevilacqua are in the Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, USA.,

    Rebecca Toroney & Philip C Bevilacqua

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  1. Rebecca Toroney
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  2. Philip C Bevilacqua
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Correspondence to Philip C Bevilacqua.

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Toroney, R., Bevilacqua, P. PKR and the ribosome compete for mRNA. Nat Chem Biol 5, 873–874 (2009). https://doi.org/10.1038/nchembio.262

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