N-terminal modification is a mechanism for regulation of protein activity, localization and degradation. A proteomic approach using β-lactone activity-based probes has identified a cysteine protease with N-terminal transpeptidase activity.
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Carrico, I. Unexpected N-terminal editing: a cysteine protease that cuts and pastes. Nat Chem Biol 4, 525–526 (2008). https://doi.org/10.1038/nchembio0908-525
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DOI: https://doi.org/10.1038/nchembio0908-525