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Nature Chemical Biology 4, 527 - 528 (2008)
doi:10.1038/nchembio0908-527
Cross-dressing proteins by olefin metathesis
Kent Kirshenbaum1 & Paramjit S Arora1
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Kent Kirshenbaum and Paramjit S. Arora are in the Department of Chemistry, New York University, 100 Washington Square East, New York, New York 10003, USA.
e-mail: kent@nyu.edu or e-mail: arora@nyu.edu
Abstract
Chemists have established numerous methods for performing protein conjugations, but metathesis catalysts have largely remained absent from this toolkit. Evidence that proteins bearing allylsulfides undergo cross-metathesis with chosen alkenes in aqueous conditions will allow chemists to harness the power of metathesis catalysts for modifying biomolecules and other water-soluble compounds.
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