Leucascandrolide A and neopeltolide are structurally related natural products with potent growth inhibitory activity. The synthesis of a designed analog of leucascandrolide A and its evaluation in a yeast haploinsufficiency screen has revealed the cytochrome bc1 complex as a molecular target of these compounds.
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Altmann, KH., Carreira, E. Unraveling a molecular target of macrolides. Nat Chem Biol 4, 388–389 (2008). https://doi.org/10.1038/nchembio0708-388
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DOI: https://doi.org/10.1038/nchembio0708-388
