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Brief Communication

Nature Chemical Biology 4, 238–240 (1 April 2008) | doi:10.1038/nchembio.75

Synthetic GPI array to study antitoxic malaria response

Faustin Kamena , Marco Tamborrini , Xinyu Liu , Yong-Uk Kwon , Fiona Thompson , Gerd Pluschke & Peter H Seeberger

Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI antibody response needs to be understood to aid the design of an efficient carbohydrate-based antitoxin vaccine.