A20 protein, a regulator of inflammation and cell survival, modulates cellular signaling via two apparently opposite enzyme activities. Recent studies elucidate the unusual structural organization of the A20 protease domain and provide new mechanistic insights into its biological function.
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PTMs in Conversation: Activity and Function of Deubiquitinating Enzymes Regulated via Post-Translational Modifications
Cell Biochemistry and Biophysics Open Access 12 April 2011
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Balakirev, M., Wilkinson, K. OTU takes the chains OUT. Nat Chem Biol 4, 227–228 (2008). https://doi.org/10.1038/nchembio0408-227
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DOI: https://doi.org/10.1038/nchembio0408-227
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PTMs in Conversation: Activity and Function of Deubiquitinating Enzymes Regulated via Post-Translational Modifications
Cell Biochemistry and Biophysics (2011)