Crystallographic analysis has been instrumental in revealing the molecular basis for the pharmacological properties of several natural and synthetic ligands of steroid receptors, but it is often a long and arduous process. A new method for stabilizing these receptors greatly accelerates this process, allowing generation of apo receptor crystals and the comparison of multiple structures to define pathway-specific interactions.
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Mader, S. Fast-tracking steroid receptor crystallization. Nat Chem Biol 4, 226–227 (2008). https://doi.org/10.1038/nchembio0408-226
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DOI: https://doi.org/10.1038/nchembio0408-226
