Access

Brief Communication

Nature Chemical Biology 4, 232–234 (1 April 2008) | doi:10.1038/nchembio.73

Genetically encoding N|[epsi]|-acetyllysine in recombinant proteins

Heinz Neumann , Sew Y Peak-Chew & Jason W Chin

N|[epsi]|-acetylation of lysine (1) is a reversible post-translational modification with a regulatory role that rivals that of phosphorylation in eukaryotes. No general methods exist to synthesize proteins containing N|[epsi]|-acetyllysine (2) at defined sites.