Brief Communication abstract
Nature Chemical Biology 4, 238 - 240 (2008)
Published online: 2 March 2008 | doi:10.1038/nchembio.75
Synthetic GPI array to study antitoxic malaria response
Faustin Kamena1, Marco Tamborrini2, Xinyu Liu1, Yong-Uk Kwon1, Fiona Thompson3, Gerd Pluschke2 & Peter H Seeberger1
Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI antibody response needs to be understood to aid the design of an efficient carbohydrate-based antitoxin vaccine. We present a versatile approach based on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria.
- Laboratory for Organic Chemistry, Swiss Federal Institute of Technology (ETH) Zurich, Wolfgang-Pauli-Str. 10, 8093 Zurich, Switzerland.
- Swiss Tropical Institute, Socinstr. 57, 4002 Basel, Switzerland.
- Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Churchill Hospital, Old Road, Oxford OX3 7LJ, UK.
Correspondence to: Peter H Seeberger1 e-mail: seeberger@org.chem.ethz.ch