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Nature Chemical Biology 4, 86–88 (1 February 2008) | doi:10.1038/nchembio0208-86
Small molecule versus DNA repair nanomachine
Abstract
The efficient sensing of DSBs and the coordination of this detection event with cell cycle progression or apoptosis is the responsibility of the Mre11-Rad50-Nbs1 (MRN) protein complex. The central role of this complex in signaling the presence of DSBs and then coordinating the cellular repair response suggests that an inhibitor of MRN may sensitize tumors to agents that induce DNA breaks.
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