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Small molecule versus DNA repair nanomachine

Nature Chemical Biology volume 4, pages 86–88 (2008)Cite this article

A Corrigendum to this article was published on 01 March 2009

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The MRN protein megacomplex mediates repair of double-stranded DNA breaks (DSBs) by tethering together broken ends of chromosomes and signaling a cascade of events required for DNA repair. The first small-molecule inhibitor that disrupts MRN function provides a valuable new tool for functional studies of DSB repair in cells.

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Figure 1: Architecture of the MRN complex bound to DNA DSBs and the proposed inhibition mechanism of mirin.

Change history

  • 13 February 2009

    In the version of this article initially published, the chemical structure of mirin in Figure 1b was incorrect. The error has been corrected in the HTML and PDF versions of the article.

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  1. James T. Stivers is in the Department of Pharmacology and Molecular Sciences, Johns Hopkins Medical School, 725 North Wolfe Street, Baltimore, Maryland 21205, USA. jstivers@jhmi.edu,

    James T Stivers

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  1. James T Stivers
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Stivers, J. Small molecule versus DNA repair nanomachine. Nat Chem Biol 4, 86–88 (2008). https://doi.org/10.1038/nchembio0208-86

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