Isoginkgetin has been identified as a general inhibitor of pre-mRNA splicing using an in vivo screening assay. This and related inhibitors will not only be useful as tools to decipher the roles of the individual components of the spliceosome but may also serve as therapeutics.
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Disney, M. Short-circuiting RNA splicing. Nat Chem Biol 4, 723–724 (2008). https://doi.org/10.1038/nchembio1208-723
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DOI: https://doi.org/10.1038/nchembio1208-723
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