Supplementary information

From the following article

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

Beth Apsel, Jimmy A Blair, Beatriz Gonzalez, Tamim M Nazif, Morri E Feldman, Brian Aizenstein, Randy Hoffman, Roger L Williams, Kevan M Shokat & Zachary A Knight

Nature Chemical Biology 4, 691 - 699 (2008) Published online: 12 October 2008

doi:10.1038/nchembio.117

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Supplementary Figures 1–5, Supplementary Tables 1–3 and Supplementary Methods

Supplementary Movie 1

Conformational changes in Src associated with PP121 binding.

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