The execution phase of cell death is driven by specific proteolytic signaling through cleavage of proteins by caspases. Within the mix of hundreds of newly identified caspase substrates lie the crucial proteolytic events whose sum defines the unique morphology known as apoptosis.
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Enoksson, M., Salvesen, G. Proteolytic needles in the cellular haystack. Nat Chem Biol 4, 651–652 (2008). https://doi.org/10.1038/nchembio1108-651
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DOI: https://doi.org/10.1038/nchembio1108-651