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Nature Chemical Biology 4, 583–584 (1 October 2008) | doi:10.1038/nchembio1008-583

Small molecules can have big effects on endurance

Keith Baar & D Grahame Hardie

Skeletal muscle is a highly adaptable tissue that responds to repeated exercise by altering its contractile properties and its metabolism. For example, endurance training results in an increased capacity to generate energy (in the form of ATP) from aerobic pathways.