Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Meeting Report
  • Published:

Drugs in action

How do drugs work? What molecular changes do they cause in cells and in organisms? Is there a paradigm shift in the way we can predict and appreciate the impact of small molecules on biological systems in the 21st century? These were some of the questions addressed at a meeting in Vienna in August 2007.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Small-molecule structures.
Figure 2: Cartoon of the interaction network of tyrosine kinase inhibitors imatinib, dasatinib and nilotinib with their respective protein targets.

References

  1. Oltersdorf, T. et al. Nature 435, 677–681 (2005).

    Article  CAS  Google Scholar 

  2. Chiang, K.P., Niessen, S., Saghatelian, A. & Cravatt, B.F. Chem. Biol. 13, 1041–1050 (2006).

    Article  CAS  Google Scholar 

  3. Johnson, R.J., McCoy, J.G., Bingman, C.A., Phillips, G.N. Jr. & Raines, R.T. J. Mol. Biol. 368, 434–449 (2007).

    Article  CAS  Google Scholar 

  4. Adrian, F.J. et al. Nat. Chem. Biol. 2, 95–102 (2006).

    Article  CAS  Google Scholar 

  5. Hantschel, O. et al. Cell 112, 845–857 (2003).

    Article  CAS  Google Scholar 

  6. Bantscheff, M. et al. Nat. Biotechnol. 25, 1035–1044 (2007).

    Article  CAS  Google Scholar 

  7. Rix, U. et al. Blood 110, 4055–4063 (2007).

    Article  CAS  Google Scholar 

  8. Hantschel, O. et al. Proc. Natl. Acad. Sci. USA 104, 13283–13288 (2007).

    Article  CAS  Google Scholar 

  9. Peterson, J.R. & Mitchison, T.J. Chem. Biol. 9, 1275–1285 (2002).

    Article  CAS  Google Scholar 

  10. Eggert, U.S. et al. PLoS Biol. 2, e379 (2004).

    Article  Google Scholar 

  11. Lenart, P. et al. Curr. Biol. 17, 304–315 (2007).

    Article  CAS  Google Scholar 

  12. Petronczki, M., Glotzer, M., Kraut, N. & Peters, J.M. Dev. Cell 12, 713–725 (2007).

    Article  CAS  Google Scholar 

  13. Swanton, C. et al. Cancer Cell 11, 498–512 (2007).

    Article  CAS  Google Scholar 

  14. Min, J. et al. Nat. Chem. Biol. 3, 55–59 (2007).

    Article  CAS  Google Scholar 

  15. Kwok, T.C. et al. Nature 441, 91–95 (2006).

    Article  CAS  Google Scholar 

  16. Fuss, B., Becker, T., Zinke, I. & Hoch, M. Nature 444, 945–948 (2006).

    Article  CAS  Google Scholar 

  17. Hafner, M. et al. Nature 444, 941–944 (2006).

    Article  CAS  Google Scholar 

  18. Paolini, G.V., Shapland, R.H., van Hoorn, W.P., Mason, J.S. & Hopkins, A.L. Nat. Biotechnol. 24, 805–815 (2006).

    Article  CAS  Google Scholar 

  19. Freiberg, C., Brunner, N., Macko, L. & Fischer, H.P. Mol. Cell. Proteomics 5, 2326–2335 (2006).

    Article  CAS  Google Scholar 

  20. Fishman, M.C. & Porter, J.A. Nature 437, 491–493 (2005).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The meeting was sponsored by the European Molecular Biology Organization, ACS Chemical Biology, the Austrian Academy of Sciences, Boehringer Ingelheim, CeMM, GEN-AU, Nature Chemical Biology, Novartis, Roche, Thermo Fisher Scientific and Waters.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Eggert, U., Superti-Furga, G. Drugs in action. Nat Chem Biol 4, 7–11 (2008). https://doi.org/10.1038/nchembio0108-7

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio0108-7

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing