Chemical probes reveal Hsp90 to be a key molecule for the control of apoptosis in small-cell lung cancer—with important implications for Hsp90 biology and cancer treatment.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Identification of HSP90 inhibitors as a novel class of senolytics
Nature Communications Open Access 04 September 2017
-
CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells
Scientific Reports Open Access 08 January 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Kim Caesar
References
McDonald, E., Jones, J. & Workman, P. Curr. Top. Med. Chem. 6, 1091–1107 (2006).
Chiosis, G., Caldas Lopez, E. & Solit, D. Curr. Opin. Investig. Drugs 7, 534–541 (2006).
Pacey, S., Banerji, U., Judson, I. & Workman, P. Handb. Exp. Pharmacol. 172, 331–358 (2006).
Workman, P., Neckers, L., Burrows, F. & Rosen, N. Ann. NY Acad. Sci., published online 18 May 2007 (doi:10.1196/annals1391.012).
Rodina, A. et al. Nat. Chem. Biol. 3, 498–507 (2007).
Ritossa, F. Cell Stress Chaperones 1, 97–98 (1996).
Westerheide, S.D. & Morimoto, R.I. J. Biol. Chem. 280, 33097–33100 (2005).
Kamal, A. et al. Nature 425, 407–410 (2003).
Chiosis, G. & Neckers, L. ACS. Chem. Biol. 1, 279–284 (2006).
Pearl, L.H. & Prodromou, C. Annu. Rev. Biochem. 75, 271–294 (2006).
Hostein, I. et al. Cancer Res. 61, 4003–4009 (2001).
Banerji, U. et al. Clin. Cancer Res. 11, 7023–7032 (2005).
Nylansted, J. et al. Cancer Res. 62, 7139–7142 (2002).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
P.W. has been involved in a funded research collaboration with Vernalis to develop Hsp90 inhibitors and the agents identified have been licensed to Novartis. P.W. is also a consultant for Novartis.
Rights and permissions
About this article
Cite this article
Workman, P., Powers, M. Chaperoning cell death: a critical dual role for Hsp90 in small-cell lung cancer. Nat Chem Biol 3, 455–457 (2007). https://doi.org/10.1038/nchembio0807-455
Issue Date:
DOI: https://doi.org/10.1038/nchembio0807-455
This article is cited by
-
Activating CCT2 triggers Gli-1 activation during hypoxic condition in colorectal cancer
Oncogene (2020)
-
Identification of HSP90 inhibitors as a novel class of senolytics
Nature Communications (2017)
-
Regioselective synthesis and biological studies of novel 1-aryl-3, 5-bis (het) aryl pyrazole derivatives as potential antiproliferative agents
Molecular and Cellular Biochemistry (2017)
-
CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells
Scientific Reports (2016)
-
Perifosine Induces Cell Apoptosis in Human Osteosarcoma Cells: New Implication for Osteosarcoma Therapy?
Cell Biochemistry and Biophysics (2013)
