Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
News and Views
Nature Chemical Biology 3, 307–309 (1 June 2007) | doi:10.1038/nchembio0607-307
A sugar-coated switch for cellular growth and arrest
Abstract
Protein glycosylation has an important role in many cellular processes, including cell growth, cell–cell interactions, cancer metastasis, differentiation and development. Using a systems-level approach to investigate the connection between glycosylation and cellular function, Lau et al. present a fine-tuning mechanism for switching from growth to arrest in cells based on the flux of UDP-GlcNAc through the Golgi and the extent of N-glycan branching of growth factor receptors.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
