Guanine-rich quadruplex-forming sequences within DNA and RNA are prevalent and are suspected of regulating telomere replication, transcription and pre-mRNA splicing. The recent discovery of quadruplex-forming sequences in the 5′ untranslated regions of various proto-oncogenes suggests an important role for such sequences in inhibition of mRNA translation.
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Armitage, B. The rule of four. Nat Chem Biol 3, 203–204 (2007). https://doi.org/10.1038/nchembio0407-203
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DOI: https://doi.org/10.1038/nchembio0407-203