Pharmacological and genetic modulators of voltage-gated Ca2+ channel (CaV) activity have been useful tools for understanding and modulating excitable cell function. A new method combines these approaches to provide pharmacological control of a genetically encoded suppressor of CaV activity.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Evans, R.M. & Zamponi, G.W. Trends Neurosci. 29, 617–624 (2006).
Altier, C. et al. J. Neurosci. 27, 6363–6373 (2007).
Nerbonne, J.M. & Kass, R.S. Physiol. Rev. 85, 1205–1253 (2005).
Yang, T., Suhail, Y., Dalton, S., Kernan, T. & Colecraft, H.M. Nat. Chem. Biol. 3, 795–804 (2007).
Beguin, P. et al. Nature 411, 701–706 (2001).
Chen, H., Puhl, H.L. III, Niu, S.L., Mitchell, D.C. & Ikeda, S.R. J. Neurosci. 25, 9762–9772 (2005).
Crabtree, G.R. & Schreiber, S.L. Trends Biochem. Sci. 21, 418–422 (1996).
Inoue, T., Heo, W.D., Grimley, J.S., Wandless, T.J. & Meyer, T. Nat. Methods 2, 415–418 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nitabach, M. Chemical genetic modification of Ca2+ channel activity. Nat Chem Biol 3, 754–755 (2007). https://doi.org/10.1038/nchembio1207-754
Issue Date:
DOI: https://doi.org/10.1038/nchembio1207-754