A recently characterized 'M-box' genetic switch from bacteria is proposed to directly sense cellular Mg2+ levels through the conformation of its newly synthesized RNA. This Mg2+-sensing riboswitch controls transcription termination in front of a Mg2+ transporter gene, thus introducing a new and direct level of genetic regulation to metal ion homeostasis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Dann, C.E. III et al. Cell 130, 878–892 (2007).
Barrick, J.E. et al. Proc. Natl. Acad. Sci. USA 101, 6421–6426 (2004).
Coppins, R.L., Hall, K.B. & Groisman, E.A. Curr. Opin. Microbiol. 10, 176–181 (2007).
Winkler, W.C. & Dann, C.E. III. Nat. Struct. Mol. Biol. 13, 569–571 (2006).
Tottey, S., Harvie, D.R. & Robinson, N.J. Acc. Chem. Res. 38, 775–783 (2005).
Cromie, M.J., Shi, Y., Latifi, T. & Groisman, E.A. Cell 125, 71–84 (2006).
Greive, S.J. & von Hippel, P.V. Nat. Rev. Mol. Cell Biol. 6, 221–232 (2005).
Woodson, S.A. Curr. Opin. Chem. Biol. 9, 104–109 (2005).
Travers, K.J., Boyd, N. & Herschlag, D. RNA 13, 1205–1213 (2007).
Maguire, M.E. Curr. Opin. Struct. Biol. 16, 432–438 (2006).
Hattori, M., Tanaka, Y., Fukai, S., Ishitani, R. & Nureki, O. Nature 448, 1072–1075 (2007).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DeRose, V. Sensing cellular magnesium with RNA. Nat Chem Biol 3, 693–694 (2007). https://doi.org/10.1038/nchembio1107-693
Issue Date:
DOI: https://doi.org/10.1038/nchembio1107-693
